Swainsonine

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Cat.No. 3208 - Swainsonine | C8H15NO3 | CAS No. 72741-87-8
Description: Inhibitor of α-mannosidase II
Chemical Name: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Datasheet
Citations (1)
Literature

Biological Activity

Inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.

Technical Data

M. Wt 173.21
Formula C8H15NO3
Storage Store at -20°C
CAS Number 72741-87-8
PubChem ID 51683
InChI Key FXUAIOOAOAVCGD-WCTZXXKLSA-N
Smiles O[C@@H]2[C@H](O)CN1CCC[C@@H](O)[C@@]12[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.66 50

Preparing Stock Solutions

The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.77 mL 28.87 mL 57.73 mL
5 mM 1.15 mL 5.77 mL 11.55 mL
10 mM 0.58 mL 2.89 mL 5.77 mL
50 mM 0.12 mL 0.58 mL 1.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tulsiani et al (1982) Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 257 7936 PMID: 6806288

Olden et al (1991) The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 50 285 PMID: 1754603

Sun et al (2007) Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 14 353 PMID: 17097281


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Keywords: Swainsonine, supplier, inhibitors, inhibits, α-mannosidase, alpha-mannosidase, II, Glycosylases, Carbohydrate, Metabolism, Glycosylases, Glycosylases, Tocris Bioscience

1 Citation for Swainsonine

Citations are publications that use Tocris products. Selected citations for Swainsonine include:

Tareen et al (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 22 575 PMID: 24419083


Do you know of a great paper that uses Swainsonine from Tocris? If so please let us know.

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