Swainsonine

Pricing Availability   Qty
Cat.No. 3208 - Swainsonine | C8H15NO3 | CAS No. 72741-87-8
Description: Inhibitor of α-mannosidase II
Chemical Name: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.

Technical Data

M. Wt 173.21
Formula C8H15NO3
Storage Store at -20°C
CAS Number 72741-87-8
PubChem ID 51683
InChI Key FXUAIOOAOAVCGD-WCTZXXKLSA-N
Smiles O[C@@H]2[C@H](O)CN1CCC[C@@H](O)[C@@]12[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.66 50

Preparing Stock Solutions

The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 11.55 mL 57.73 mL 115.47 mL
2.5 mM 2.31 mL 11.55 mL 23.09 mL
5 mM 1.15 mL 5.77 mL 11.55 mL
25 mM 0.23 mL 1.15 mL 2.31 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Tulsiani et al (1982) Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 257 7936 PMID: 6806288

Olden et al (1991) The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 50 285 PMID: 1754603

Sun et al (2007) Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 14 353 PMID: 17097281


If you know of a relevant reference for Swainsonine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glycosylase Inhibitors

Keywords: Swainsonine, Swainsonine supplier, inhibitors, inhibits, α-mannosidase, alpha-mannosidase, II, Glycosylases, Carbohydrate, Metabolism, 3208, Tocris Bioscience

2 Citations for Swainsonine

Citations are publications that use Tocris products. Selected citations for Swainsonine include:

Tareen et al (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 22 575 PMID: 24419083

Nacev et al (2011) The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem 286 44045 PMID: 22025615


Do you know of a great paper that uses Swainsonine from Tocris? Please let us know.

Reviews for Swainsonine

There are currently no reviews for this product. Be the first to review Swainsonine and earn rewards!

Have you used Swainsonine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells