Swainsonine

Pricing Availability   Qty
Cat.No. 3208 - Swainsonine | C8H15NO3 | CAS No. 72741-87-8
Description: Inhibitor of α-mannosidase II
Chemical Name: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Datasheet
Citations (3)
Reviews

Biological Activity for Swainsonine

Swainsonine is an inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.

Technical Data for Swainsonine

M. Wt 173.21
Formula C8H15NO3
Storage Store at -20°C
CAS Number 72741-87-8
PubChem ID 51683
InChI Key FXUAIOOAOAVCGD-WCTZXXKLSA-N
Smiles O[C@@H]2[C@H](O)CN1CCC[C@@H](O)[C@@]12[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Swainsonine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.66 50

Preparing Stock Solutions for Swainsonine

The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 11.55 mL 57.73 mL 115.47 mL
2.5 mM 2.31 mL 11.55 mL 23.09 mL
5 mM 1.15 mL 5.77 mL 11.55 mL
25 mM 0.23 mL 1.15 mL 2.31 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Swainsonine

Certificate of Analysis / Product Datasheet
Select another batch:

References for Swainsonine

References are publications that support the biological activity of the product.

Tulsiani et al (1982) Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 257 7936 PMID: 6806288

Olden et al (1991) The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 50 285 PMID: 1754603

Sun et al (2007) Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 14 353 PMID: 17097281


If you know of a relevant reference for Swainsonine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glycosylase Inhibitors

Keywords: Swainsonine, Swainsonine supplier, inhibitors, inhibits, α-mannosidase, alpha-mannosidase, II, Glycosylases, Carbohydrate, Metabolism, 3208, Tocris Bioscience

3 Citations for Swainsonine

Citations are publications that use Tocris products. Selected citations for Swainsonine include:

Tareen et al (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 22 575 PMID: 24419083

Skrenkova et al (2018) N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. Front Mol Neurosci 11 188 PMID: 29915530

Nacev et al (2011) The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem 286 44045 PMID: 22025615


Do you know of a great paper that uses Swainsonine from Tocris? Please let us know.

Reviews for Swainsonine

There are currently no reviews for this product. Be the first to review Swainsonine and earn rewards!

Have you used Swainsonine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review