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Description: Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)
Chemical Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Purity: ≥99% (HPLC)
Biological Activity for Sulindac
Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo. Widely used anti-inflammatory agent.
Technical Data for Sulindac
| M. Wt | 356.41 |
| Formula | C20H17FO3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 38194-50-2 |
| PubChem ID | 1548887 |
| InChI Key | MLKXDPUZXIRXEP-MFOYZWKCSA-N |
| Smiles | FC1=CC=C(/C(C(C)=C3CC(O)=O)=C\C2=CC=C(S(C)=O)C=C2)C3=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Sulindac
References for Sulindac
References are publications that support the biological activity of the product.
Haanen (2001) Sulindac and its derivatives: a novel class of anticancer agents. Curr.Opin.Investig.Drugs 2 677 PMID: 11569947
Shen and Winter (1977) Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 12 90 PMID: 343530
Taylor et al (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res. 60 6607 PMID: 11118042
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Keywords: Sulindac, Sulindac supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, 1707, Tocris Bioscience
1 Citation for Sulindac
Citations are publications that use Tocris products. Selected citations for Sulindac include:
Hagen et al (2015) Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells 4 84 PMID: 25679284
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