Sulindac

Discontinued Product

Sulindac (Cat. No. 1707) has been withdrawn from sale for commercial reasons.
Description: Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)
Chemical Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for Sulindac

Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo. Widely used anti-inflammatory agent.

Technical Data for Sulindac

M. Wt 356.41
Formula C20H17FO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 38194-50-2
PubChem ID 1548887
InChI Key MLKXDPUZXIRXEP-MFOYZWKCSA-N
Smiles FC1=CC=C(/C(C(C)=C3CC(O)=O)=C\C2=CC=C(S(C)=O)C=C2)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Sulindac

References are publications that support the biological activity of the product.

Haanen (2001) Sulindac and its derivatives: a novel class of anticancer agents. Curr.Opin.Investig.Drugs 2 677 PMID: 11569947

Shen and Winter (1977) Chemical and biological studies on indomethacin, sul. and their analogs. Adv.Drug Res. 12 90 PMID: 343530

Taylor et al (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res. 60 6607 PMID: 11118042

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Keywords: Sulindac, Sulindac supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, 1707, Tocris Bioscience

1 Citation for Sulindac

Citations are publications that use Tocris products. Selected citations for Sulindac include:

Hagen et al (2015) Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells 4 84 PMID: 25679284


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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