Sulindac

Discontinued Product

Unfortunately Sulindac (Cat. No. 1707) has been withdrawn from sale for commercial reasons.
Cat.No. 1707 - Sulindac | C20H17FO3S | CAS No. 38194-50-2
Description: Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)
Chemical Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo. Widely used anti-inflammatory agent.

Technical Data

M. Wt 356.41
Formula C20H17FO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 38194-50-2
PubChem ID 1548887
InChI Key MLKXDPUZXIRXEP-MFOYZWKCSA-N
Smiles FC1=CC=C(/C(C(C)=C3CC(O)=O)=C\C2=CC=C(S(C)=O)C=C2)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 356.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Haanen (2001) Sulindac and its derivatives: a novel class of anticancer agents. Curr.Opin.Investig.Drugs 2 677 PMID: 11569947

Shen and Winter (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv.Drug Res. 12 90 PMID: 343530

Taylor et al (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. Cancer Res. 60 6607 PMID: 11118042

View Related Products by Target

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Keywords: Sulindac, supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience

1 Citation for Sulindac

Citations are publications that use Tocris products. Selected citations for Sulindac include:

Hagen et al (2015) Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells 4 84 PMID: 25679284


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