Strychnine hydrochloride

Discontinued Product

Unfortunately Strychnine hydrochloride (Cat. No. 2785) has been withdrawn from sale for commercial reasons.
Cat.No. 2785 - Strychnine hydrochloride | C21H22N2O2.HCl | CAS No. 1421-86-9
Description: Competitive glycine receptor antagonist
Chemical Name: Strychnidin-10-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α7 receptors and non-competitive antagonism at α4β2 receptors.

Technical Data

M. Wt 370.87
Formula C21H22N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1421-86-9
Smiles [H][C@]45C[C@]6([H])[C@@]2([H])C7CC(N(C2[C@]34CCN5CC6=CCO7)C1=C3C=CC=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 370.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.48 mL 26.96 mL
5 mM 0.54 mL 2.7 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Mataubayashi et al (1998) Strychnine: a potent competitive antagonist of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons. J.Pharmacol.Exp.Ther. 284 904 PMID: 9495848

Betz et al (2006) Glycine receptors: recent insights into their structural organization and functional diversity. J.Neurochem. 67 1600 PMID:

View Related Products by Product Action

View all Glycine Receptor Antagonists

Keywords: Strychnine hydrochloride, supplier, Competitive, glycine, receptors, antagonists, Nicotinic, GlyR, Acetylcholine, Non-Selective, Subtypes, nAChR, a7, α7, alpha7, α4β2, a4b2, Glycine, Receptors, Tocris Bioscience

Citations for Strychnine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Strychnine hydrochloride.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Strychnine hydrochloride

Protocols

TODO: Add Protocols