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Submit ReviewStrychnine hydrochloride
Description: Competitive glycine receptor antagonist
Chemical Name: Strychnidin-10-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Strychnine hydrochloride
Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α7 receptors and non-competitive antagonism at α4β2 receptors.
Technical Data for Strychnine hydrochloride
| M. Wt | 370.87 |
| Formula | C21H22N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1421-86-9 |
| Smiles | [H][C@]45C[C@]6([H])[C@@]2([H])C7CC(N(C2[C@]34CCN5CC6=CCO7)C1=C3C=CC=C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Strychnine hydrochloride
References for Strychnine hydrochloride
References are publications that support the biological activity of the product.
Mataubayashi et al (1998) Strychnine: a potent competitive antagonist of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons. J.Pharmacol.Exp.Ther. 284 904 PMID: 9495848
Betz et al (2006) Glycine receptors: recent insights into their structural organization and functional diversity. J.Neurochem. 67 1600
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Keywords: Strychnine hydrochloride, Strychnine hydrochloride supplier, Competitive, glycine, receptors, antagonists, Nicotinic, GlyR, Acetylcholine, Non-Selective, Subtypes, nAChR, a7, α7, alpha7, α4β2, a4b2, Glycine, Receptors, (Non-selective), 2785, Tocris Bioscience
Citations for Strychnine hydrochloride
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