Strychnine hydrochloride

Discontinued Product

Unfortunately Strychnine hydrochloride (Cat. No. 2785) has been withdrawn from sale for commercial reasons.
Cat.No. 2785 - Strychnine hydrochloride | C21H22N2O2.HCl | CAS No. 1421-86-9
Description: Competitive glycine receptor antagonist
Chemical Name: Strychnidin-10-one hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α7 receptors and non-competitive antagonism at α4β2 receptors.

Technical Data

M. Wt 370.87
Formula C21H22N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1421-86-9
Smiles [H][C@]45C[C@]6([H])[C@@]2([H])C7CC(N(C2[C@]34CCN5CC6=CCO7)C1=C3C=CC=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 370.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.48 mL 26.96 mL
5 mM 0.54 mL 2.7 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Mataubayashi et al (1998) Strychnine: a potent competitive antagonist of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons. J.Pharmacol.Exp.Ther. 284 904 PMID: 9495848

Betz et al (2006) Glycine receptors: recent insights into their structural organization and functional diversity. J.Neurochem. 67 1600 PMID:

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Keywords: Strychnine hydrochloride, supplier, Competitive, glycine, receptors, antagonists, Nicotinic, GlyR, Acetylcholine, Non-Selective, Subtypes, nAChR, a7, α7, alpha7, α4β2, a4b2, Glycine, Receptors, Tocris Bioscience

Citations for Strychnine hydrochloride

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Pathways for Strychnine hydrochloride


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