Strychnine hydrochloride

Discontinued Product

Strychnine hydrochloride (Cat. No. 2785) has been withdrawn from sale for commercial reasons.
Cat.No. 2785 - Strychnine hydrochloride | C21H22N2O2.HCl | CAS No. 1421-86-9
Description: Competitive glycine receptor antagonist
Chemical Name: Strychnidin-10-one hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α7 receptors and non-competitive antagonism at α4β2 receptors.

Technical Data

M. Wt 370.87
Formula C21H22N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1421-86-9
Smiles [H][C@]45C[C@]6([H])[C@@]2([H])C7CC(N(C2[C@]34CCN5CC6=CCO7)C1=C3C=CC=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the biological activity of the product.

Mataubayashi et al (1998) Strychnine: a potent competitive antagonist of α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons. J.Pharmacol.Exp.Ther. 284 904 PMID: 9495848

Betz et al (2006) Glycine receptors: recent insights into their structural organization and functional diversity. J.Neurochem. 67 1600

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Keywords: Strychnine hydrochloride, Strychnine hydrochloride supplier, Competitive, glycine, receptors, antagonists, Nicotinic, GlyR, Acetylcholine, Non-Selective, Subtypes, nAChR, a7, α7, alpha7, α4β2, a4b2, Glycine, Receptors, (Non-selective), 2785, Tocris Bioscience

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