Strontium chloride
Biological Activity
Calcium sensing receptor (CaSR) agonist. Activates ERK1/2 signaling, intracellular calcium mobilization, and calcitonin secretion. Enhances osteogenic differentiation of mesenchymal stem cells.
Technical Data
| M. Wt | 158.53 |
| Formula | SrCl2 |
| Storage | Desiccate at RT |
| CAS Number | 10476-85-4 |
| PubChem ID | 61520 |
| InChI Key | AHBGXTDRMVNFER-UHFFFAOYSA-L |
| Smiles | Cl[Sr]Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.85 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 158.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.31 mL | 31.54 mL | 63.08 mL |
| 5 mM | 1.26 mL | 6.31 mL | 12.62 mL |
| 10 mM | 0.63 mL | 3.15 mL | 6.31 mL |
| 50 mM | 0.13 mL | 0.63 mL | 1.26 mL |
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References
References are publications that support the products' biological activity.
Thomsen et al (2012) Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. J.Pharmacol.Exp.Ther. 343 638 PMID: 22942242
Yang et al (2011) Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling. Stem Cells 29 981 PMID: 21563277
If you know of a relevant reference for Strontium chloride, please let us know.
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Keywords: calcium sensing receptor CaSR agonists ERK1/2 calcitonin secretion osteogenic differentiation stem cells Calcium-Sensing Receptor
Citations for Strontium chloride
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