Strontium chloride

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Cat.No. 4749 - Strontium chloride | SrCl2 | CAS No. 10476-85-4
Description: Calcium sensing receptor (CaSR) agonist
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Biological Activity

Calcium sensing receptor (CaSR) agonist. Activates ERK1/2 signaling, intracellular calcium mobilization, and calcitonin secretion. Enhances osteogenic differentiation of mesenchymal stem cells.

Technical Data

M. Wt 158.53
Formula SrCl2
Storage Desiccate at RT
CAS Number 10476-85-4
PubChem ID 61520
InChI Key AHBGXTDRMVNFER-UHFFFAOYSA-L
Smiles Cl[Sr]Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 158.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.31 mL 31.54 mL 63.08 mL
5 mM 1.26 mL 6.31 mL 12.62 mL
10 mM 0.63 mL 3.15 mL 6.31 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Thomsen et al (2012) Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. J.Pharmacol.Exp.Ther. 343 638 PMID: 22942242

Yang et al (2011) Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling. Stem Cells 29 981 PMID: 21563277


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Keywords: Strontium chloride, supplier, calcium, sensing, receptor, CaSR, agonists, ERK1/2, calcitonin, secretion, osteogenic, differentiation, stem, cells, Calcium-Sensing, Receptor, Mesenchymal, Stem, Cells, Osteogenic, Stem, Cells, Calcium-Sensing, Receptor, Tocris Bioscience

Citations for Strontium chloride

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