STING Degrader N-Me-SP23

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Description: Negative control for STING Degrader SP23 (Cat. No. 8053)
Chemical Name: (2E)-N1-[6-[[2,3-Dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for STING Degrader N-Me-SP23

STING Degrader N-Me-SP23 is a negative control for STING Degrader SP23 (Cat. No. 8053).

Technical Data for STING Degrader N-Me-SP23

M. Wt 713.7
Formula C35H35N7O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2767427-87-0
Smiles O=C1C2=C(NCCCCCCNC(/C=C/C(NC3=CC=C(C=C3)NC(C4=CC=C(N(=O)=O)O4)=O)=O)=O)C=CC=C2C(N1C5C(N(C(CC5)=O)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for STING Degrader N-Me-SP23

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 71.37 100

Preparing Stock Solutions for STING Degrader N-Me-SP23

The following data is based on the product molecular weight 713.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.4 mL 7.01 mL 14.01 mL
5 mM 0.28 mL 1.4 mL 2.8 mL
10 mM 0.14 mL 0.7 mL 1.4 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets for STING Degrader N-Me-SP23

References for STING Degrader N-Me-SP23

References are publications that support the biological activity of the product.

Liu et al (2022) Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti- inflammatory efficacy. J.Med.Chem. 65 6593 PMID: 35452223

If you know of a relevant reference for STING Degrader N-Me-SP23, please let us know.

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Citations for STING Degrader N-Me-SP23

Citations are publications that use Tocris products.

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia