STF 118804

Pricing Availability Delivery Time Qty
Cat.No. 5207 - STF 118804 | C25H23N3O4S | CAS No. 894187-61-2
Description: NAMPT inhibitor; depletes leukemia stem cells
Chemical Name: 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

Compound Libraries

STF 118804 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 461.53
Formula C25H23N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 894187-61-2
PubChem ID 20916937
InChI Key DLFCEZOMHBPDGI-UHFFFAOYSA-N
Smiles O=C(C2=CC=C(C3=NC(CS(C4=CC=C(C)C=C4)(=O)=O)=C(C)O3)C=C2)NCC1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.15 100
ethanol 2.31 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 461.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Matheny et al (2013) Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem.Biol. 20 1352 PMID: 24183972


If you know of a relevant reference for STF 118804, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NAMPT Inhibitors

Keywords: STF 118804, supplier, STF118804, NAMPT, inhibitors, inhibits, potent, nicotinamide, phosphoribosyltransferase, visfatin, PBEF1, cytotoxic, Cancer, Stem, Cells, NAMPT, NAMPT, Tocris Bioscience

Citations for STF 118804

Citations are publications that use Tocris products.

Currently there are no citations for STF 118804. Do you know of a great paper that uses STF 118804 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cancer Metabolism

Cancer Metabolism Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.

Pathways for STF 118804

Protocols

TODO: Add Protocols