STF 118804

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Description: NAMPT inhibitor; depletes leukemia stem cells
Chemical Name: 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)
Literature (1)

Biological Activity for STF 118804

STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

Technical Data for STF 118804

M. Wt 461.53
Formula C25H23N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 894187-61-2
PubChem ID 20916937
Smiles O=C(C2=CC=C(C3=NC(CS(C4=CC=C(C)C=C4)(=O)=O)=C(C)O3)C=C2)NCC1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for STF 118804

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.15 100

Preparing Stock Solutions for STF 118804

The following data is based on the product molecular weight 461.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for STF 118804

References are publications that support the biological activity of the product.

Matheny et al (2013) Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem.Biol. 20 1352 PMID: 24183972

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Keywords: STF 118804, STF 118804 supplier, STF118804, NAMPT, inhibitors, inhibits, potent, nicotinamide, phosphoribosyltransferase, visfatin, PBEF1, cytotoxic, Cancer, Stem, Cells, 5207, Tocris Bioscience

1 Citation for STF 118804

Citations are publications that use Tocris products. Selected citations for STF 118804 include:

Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867

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Reviews for STF 118804

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It works well for cell culture..
By Anonymous on 05/07/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: human astrocytes

After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.

PMID: 31439867 Reference
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Literature in this Area

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