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Nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 224.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.46 mL||22.3 mL||44.6 mL|
|5 mM||0.89 mL||4.46 mL||8.92 mL|
|10 mM||0.45 mL||2.23 mL||4.46 mL|
|50 mM||0.09 mL||0.45 mL||0.89 mL|
References are publications that support the biological activity of the product.
Baba et al (1987) Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochem.Biophys.Res.Commun. 142 128 PMID: 3028398
Riddler et al (1995) Antiretroviral activity of stav. (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 27 189 PMID: 8540743
If you know of a relevant reference for Stavudine, please let us know.
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Citations for Stavudine
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Stavudine triphosphate was studied to understand how it affects cellular synthesis of mitochondrial DNA.
Cells were grown and differentiated, as described in the text, in the presence of 0, 1, or 10 μM AZT.