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Stavudine

Cat. No. 4990 Submit a Review Datasheet / COA / SDS
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Cat.No. 4990 - Stavudine | C10H12N2O4 | CAS No. 3056-17-5
Description: Nucleoside analog; antiviral
Chemical Name: 1-[(2R,5S)-2,5-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Purity: ≥99% (HPLC)
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Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.

Compound Libraries

Stavudine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 224.21
Formula C10H12N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 3056-17-5
PubChem ID 18283
InChI Key XNKLLVCARDGLGL-JGVFFNPUSA-N
Smiles [H]C1=C([H])[C@@H](O[C@@H]1CO)N1C=C(C)C(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.42 100
DMSO 22.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 224.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.46 mL 22.3 mL 44.6 mL
5 mM 0.89 mL 4.46 mL 8.92 mL
10 mM 0.45 mL 2.23 mL 4.46 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Baba et al (1987) Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochem.Biophys.Res.Commun. 142 128 PMID: 3028398

Riddler et al (1995) Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 27 189 PMID: 8540743

If you know of a relevant reference for Stavudine, please let us know.

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Citations for Stavudine

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Literature in this Area

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