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Cat.No. 4990 - Stavudine | C10H12N2O4 | CAS No. 3056-17-5
Description: Inhibis HIV-1 replication in vitro; nucleoside analog
Chemical Name: 1-[(2R,5S)-2,5-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for Stavudine

Stavudine is a nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.

Compound Libraries for Stavudine

Stavudine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Stavudine

M. Wt 224.21
Formula C10H12N2O4
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 3056-17-5
PubChem ID 18283
Smiles [H]C1=C([H])[C@@H](O[C@@H]1CO)N1C=C(C)C(=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Stavudine

Solvent Max Conc. mg/mL Max Conc. mM
water 22.42 100
DMSO 22.42 100

Preparing Stock Solutions for Stavudine

The following data is based on the product molecular weight 224.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.46 mL 22.3 mL 44.6 mL
5 mM 0.89 mL 4.46 mL 8.92 mL
10 mM 0.45 mL 2.23 mL 4.46 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

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References for Stavudine

References are publications that support the biological activity of the product.

Baba et al (1987) Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochem.Biophys.Res.Commun. 142 128 PMID: 3028398

Riddler et al (1995) Antiretroviral activity of stav. (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 27 189 PMID: 8540743

If you know of a relevant reference for Stavudine, please let us know.

Keywords: Stavudine, Stavudine supplier, Nucleoside, analogues, inhibits, HIV, replication, antiviral, 2,3-Didehydro-3-deoxythymidine, DNA,, RNA, and, Protein, Synthesis, 4990, Tocris Bioscience

Citations for Stavudine

Citations are publications that use Tocris products.

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Reviews for Stavudine

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Stavudine was studied to understand how it affects cellular synthesis of mitochondrial DNA.
By Anonymous on 11/30/2019
Species: Human

Stavudine triphosphate was studied to understand how it affects cellular synthesis of mitochondrial DNA.

Cells were grown and differentiated, as described in the text, in the presence of 0, 1, or 10 μM AZT.

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