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Submit ReviewStavudine
Description: Nucleoside analog; antiviral
Chemical Name: 1-[(2R,5S)-2,5-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Purity: ≥99% (HPLC)
Biological Activity
Nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.
Compound Libraries
Stavudine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 224.21 |
| Formula | C10H12N2O4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 3056-17-5 |
| PubChem ID | 18283 |
| InChI Key | XNKLLVCARDGLGL-JGVFFNPUSA-N |
| Smiles | [H]C1=C([H])[C@@H](O[C@@H]1CO)N1C=C(C)C(=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.42 | 100 | |
| DMSO | 22.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 224.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.46 mL | 22.3 mL | 44.6 mL |
| 5 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 10 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.89 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Baba et al (1987) Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochem.Biophys.Res.Commun. 142 128 PMID: 3028398
Riddler et al (1995) Antiretroviral activity of stav. (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 27 189 PMID: 8540743
If you know of a relevant reference for Stavudine, please let us know.
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Citations for Stavudine
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