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Submit ReviewStavudine
Description: Inhibis HIV-1 replication in vitro; nucleoside analog
Chemical Name: 1-[(2R,5S)-2,5-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Purity: ≥99% (HPLC)
Biological Activity for Stavudine
Stavudine is a nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.
Compound Libraries for Stavudine
Stavudine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Stavudine
| M. Wt | 224.21 |
| Formula | C10H12N2O4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 3056-17-5 |
| PubChem ID | 18283 |
| InChI Key | XNKLLVCARDGLGL-JGVFFNPUSA-N |
| Smiles | [H]C1=C([H])[C@@H](O[C@@H]1CO)N1C=C(C)C(=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Stavudine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.42 | 100 | |
| DMSO | 22.42 | 100 |
Preparing Stock Solutions for Stavudine
The following data is based on the product molecular weight 224.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.46 mL | 22.3 mL | 44.6 mL |
| 5 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 10 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.89 mL |
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Product Datasheets for Stavudine
References for Stavudine
References are publications that support the biological activity of the product.
Baba et al (1987) Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochem.Biophys.Res.Commun. 142 128 PMID: 3028398
Riddler et al (1995) Antiretroviral activity of stav. (2',3'-didehydro-3'-deoxythymidine, D4T). Antiviral Res. 27 189 PMID: 8540743
If you know of a relevant reference for Stavudine, please let us know.
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Keywords: Stavudine, Stavudine supplier, Nucleoside, analogues, inhibits, HIV, replication, antiviral, 2,3-Didehydro-3-deoxythymidine, DNA,, RNA, and, Protein, Synthesis, 4990, Tocris Bioscience
Citations for Stavudine
Citations are publications that use Tocris products.
Currently there are no citations for Stavudine. Do you know of a great paper that uses Stavudine from Tocris? Please let us know.
Reviews for Stavudine
Average Rating: 4 (Based on 1 Review.)
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Stavudine was studied to understand how it affects cellular synthesis of mitochondrial DNA.
By
Anonymous on 11/30/2019
Species: Human
Stavudine triphosphate was studied to understand how it affects cellular synthesis of mitochondrial DNA.
Cells were grown and differentiated, as described in the text, in the presence of 0, 1, or 10 μM AZT.
