Stauprimide

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Cat.No. 3741 - Stauprimide | C35H28N4O5 | CAS No. 154589-96-5
Description: Inhibits NME2 nuclear translocation; primes ESCs for differentiation
Chemical Name: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Small molecule that primes embryonic stem cells (ESCs) for differentiation. Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human ESCs in vitro.

Technical Data

M. Wt 584.62
Formula C35H28N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 154589-96-5
PubChem ID 46245328
InChI Key MQCCJEYZKWZQHU-MPRCCEKMSA-N
Smiles O=C(NC6=O)C1=C6C4=C3C2=C1C8=C(C=CC=C8)N2[C@](C[C@@H](N(C(C9=CC=CC=C9)=O)C)[C@H]7OC)([H])O[C@]7(C)N3C5=CC=CC=C45

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 584.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.55 mL 17.11 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.86 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Zhu et al (2009) A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell. 4 416 PMID: 19427291


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Keywords: Stauprimide, Stauprimide supplier, embryonic, stem, cells, ESCs, differentiation, inhibitors, inhibits, NME2, nuclear, translocation, transcription, factors, primes, Other, Transcription, Factors, and, iPSC, 3741, Tocris Bioscience

Citations for Stauprimide

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Literature in this Area

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New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

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