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Cat.No. 3741 - Stauprimide | C35H28N4O5 | CAS No. 154589-96-5
Description: Inhibits NME2 nuclear translocation; primes ESCs for differentiation
Chemical Name: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide
Purity: ≥98% (HPLC)

Biological Activity

Small molecule that primes embryonic stem cells (ESCs) for differentiation. Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human ESCs in vitro.

Technical Data

M. Wt 584.62
Formula C35H28N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 154589-96-5
PubChem ID 46245328
Smiles O=C(NC6=O)C1=C6C4=C3C2=C1C8=C(C=CC=C8)N2[C@](C[C@@H](N(C(C9=CC=CC=C9)=O)C)[C@H]7OC)([H])O[C@]7(C)N3C5=CC=CC=C45

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Zhu et al (2009) A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell. 4 416 PMID: 19427291

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Keywords: Stauprimide, Stauprimide supplier, embryonic, stem, cells, ESCs, differentiation, inhibitors, inhibits, NME2, nuclear, translocation, transcription, factors, primes, Other, Transcription, Factors, and, iPSC, 3741, Tocris Bioscience

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