ST 91

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Cat.No. 2638 - ST 91 | C13H19N3.HCl | CAS No. 4749-61-5
Description: α2 agonist, putative α2C agonist
Chemical Name: N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

α2-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for α2 receptors over α1 receptors and acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.

Compound Libraries

ST 91 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 253.77
Formula C13H19N3.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 4749-61-5
PubChem ID 20863
InChI Key ZLRWFGBEDNTMEU-UHFFFAOYSA-N
Smiles CCC2=C(C(CC)=CC=C2)/N=C1NCCN/1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.38 100
ethanol 25.38 100
water 25.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 253.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.94 mL 19.7 mL 39.41 mL
5 mM 0.79 mL 3.94 mL 7.88 mL
10 mM 0.39 mL 1.97 mL 3.94 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Takano and Yaksh (1992) Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J.Pharmacol.Exp.Ther. 261 764 PMID: 1349648

Celly et al (1999) Cardiopulmonary effects of the α2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. J.Pharmacol.Exp.Ther. 289 712 PMID: 10215644

Graham et al (2000) Synergistic interactions between two α2-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain 85 135 PMID: 10692612


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1 Citation for ST 91

Citations are publications that use Tocris products. Selected citations for ST 91 include:

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691


Do you know of a great paper that uses ST 91 from Tocris? If so please let us know.

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Pathways for ST 91

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