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ST 91 is an α2-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for α2 receptors over α1 receptors and acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Takano and Yaksh (1992) Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J.Pharmacol.Exp.Ther. 261 764 PMID: 1349648
Celly et al (1999) Cardiopulmonary effects of the α2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. J.Pharmacol.Exp.Ther. 289 712 PMID: 10215644
Graham et al (2000) Synergistic interactions between two α2-adrenoceptor agonists, dexmedetom. and ST-91, in two substrains of Sprague-Dawley rats. Pain 85 135 PMID: 10692612
Keywords: ST 91, ST 91 supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, putative, α2C-adrenoceptor, alpha2C-adrenoceptors, α2c-adrenergic, alpha2c-adrenergic, a2c-adrenoceptor, a2c-adrenergic, Receptors, ST, Adrenergic, Alpha-2, 2638, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for ST 91 include:
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691
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