ST 1936 oxalate

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Cat.No. 4337 - ST 1936 oxalate | C13H17ClN2.C2H2O4 | CAS No. 1210-81-7
Description: Selective, high affinity 5-HT6 agonist
Chemical Name: 5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

High affinity, selective agonist of 5-HT6 receptors (Ki values are 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors respectively). Displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). Shown to increase Ca2+ concentration and phosphorylation of Fyn kinase, and regulate the activation of ERK1/2 in cloned cells.

Technical Data

M. Wt 326.78
Formula C13H17ClN2.C2H2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1210-81-7
PubChem ID 90488934
InChI Key FHSPBPPTDFRVGQ-UHFFFAOYSA-N
Smiles ClC1=CC=C(NC(C)=C2CCN(C)C)C2=C1.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 326.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.3 mL 30.6 mL
5 mM 0.61 mL 3.06 mL 6.12 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References

References are publications that support the biological activity of the product.

Riccioni et al (2011) ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned 5-HT6 receptors. Eur.J.Pharmacol. 661 8 PMID: 21549693

Valentini et al (2011) A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology 60 602 PMID: 21185318


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Keywords: ST 1936 oxalate, ST 1936 oxalate supplier, ST1936, oxalate, selective, high, affinity, 5-ht6, agonists, 5-HT6, Receptors, 4337, Tocris Bioscience

1 Citation for ST 1936 oxalate

Citations are publications that use Tocris products. Selected citations for ST 1936 oxalate include:

Yun et al (2016) Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor. Scientific Reports 6 30985 PMID: 27581523


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