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SRPIN340

Cat. No. 5063 Submit a Review Datasheet / COA / SDS
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Description: Selective SRPK1 inhibitor
Chemical Name: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SRPIN340

SRPIN340 is a selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF165 but does not affect VEGF165b expression.

Technical Data for SRPIN340

M. Wt 349.35
Formula C18H18F3N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 218156-96-8
PubChem ID 2797577
InChI Key DWFGGOFPIISJIT-UHFFFAOYSA-N
Smiles O=C(C3=CC=NC=C3)NC1=C(N2CCCCC2)C=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SRPIN340

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.94 100
1eq. HCl 17.47 50

Preparing Stock Solutions for SRPIN340

The following data is based on the product molecular weight 349.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References for SRPIN340

References are publications that support the biological activity of the product.

Gammons et al (2013) SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 54 5797 PMID: 23761094

Fukuhara et al (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 103 11329 PMID: 16840555

Oltean et al (2012) SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 40 831 PMID: 22817743

If you know of a relevant reference for SRPIN340, please let us know.

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Keywords: SRPIN340, SRPIN340 supplier, SR, Protein, Kinase, inhibitors, Phosphorylation, Inhibitor, 340(SRPIN)340, Serine-Arginine-Rich, inhibits, SRPK1, SRPK2, Other, Kinases, 5063, Tocris Bioscience

Citations for SRPIN340

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