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Biological Activity for SRPIN340
SRPIN340 is a selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF165 but does not affect VEGF165b expression.
Compound Libraries for SRPIN340
Technical Data for SRPIN340
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SRPIN340
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SRPIN340
The following data is based on the product molecular weight 349.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.86 mL||14.31 mL||28.62 mL|
|5 mM||0.57 mL||2.86 mL||5.72 mL|
|10 mM||0.29 mL||1.43 mL||2.86 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References for SRPIN340
References are publications that support the biological activity of the product.
Gammons et al (2013) SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 54 5797 PMID: 23761094
Fukuhara et al (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 103 11329 PMID: 16840555
Oltean et al (2012) SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 40 831 PMID: 22817743
If you know of a relevant reference for SRPIN340, please let us know.
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Keywords: SRPIN340, SRPIN340 supplier, SR, Protein, Kinase, inhibitors, Phosphorylation, Inhibitor, 340(SRPIN)340, Serine-Arginine-Rich, inhibits, SRPK1, SRPK2, Other, Kinases, 5063, Tocris Bioscience
Citations for SRPIN340
Citations are publications that use Tocris products.
Currently there are no citations for SRPIN340. Do you know of a great paper that uses SRPIN340 from Tocris? Please let us know.
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Literature in this Area
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