Discontinued Product

SRPIN340 (Cat. No. 5063) has been withdrawn from sale for commercial reasons.
Description: Selective SRPK1 inhibitor
Chemical Name: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for SRPIN340

SRPIN340 is a selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF165 but does not affect VEGF165b expression.

Technical Data for SRPIN340

M. Wt 349.35
Formula C18H18F3N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 218156-96-8
PubChem ID 2797577
Smiles O=C(C3=CC=NC=C3)NC1=C(N2CCCCC2)C=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SRPIN340

References are publications that support the biological activity of the product.

Gammons et al (2013) SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 54 5797 PMID: 23761094

Fukuhara et al (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 103 11329 PMID: 16840555

Oltean et al (2012) SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 40 831 PMID: 22817743

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Keywords: SRPIN340, SRPIN340 supplier, SR, Protein, Kinase, inhibitors, Phosphorylation, Inhibitor, 340(SRPIN)340, Serine-Arginine-Rich, inhibits, SRPK1, SRPK2, Other, Kinases, 5063, Tocris Bioscience

2 Citations for SRPIN340

Citations are publications that use Tocris products. Selected citations for SRPIN340 include:

Lucas et al (2018) Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 559 211-216 PMID: 29973724

Katarzyna et al (2022) Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts. EMBO J 41 e110192 PMID: 36149731

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