Home / Pharmacology / Nuclear Receptors / LXR-like Receptors / LXR-like Receptor Inverse Agonists / SR 9238

SR 9238

Cat. No. 5854 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective LXR inverse agonist
Chemical Name: Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SR 9238

SR 9238 is a potent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice.

Compound Libraries for SR 9238

SR 9238 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 9238

M. Wt 595.73
Formula C31H33NO7S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1416153-62-2
PubChem ID 71478195
InChI Key HDZWHJYZJWLTAG-UHFFFAOYSA-N
Smiles CCOC(C1=CC=C(O1)CN(S(=O)(C2=C(C=C(C=C2C)C)C)=O)CC3=CC=C(C4=CC(S(C)(=O)=O)=CC=C4)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 9238

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.57 100

Preparing Stock Solutions for SR 9238

The following data is based on the product molecular weight 595.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.39 mL 16.79 mL
5 mM 0.34 mL 1.68 mL 3.36 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for SR 9238

References are publications that support the biological activity of the product.

Griffett et al (2013) A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem.Biol. 8 559 PMID: 23237488

If you know of a relevant reference for SR 9238, please let us know.

View Related Products by Target

View Related Products by Product Action

View all LXR-like Receptor Inverse Agonists

Keywords: SR 9238, SR 9238 supplier, SR9238, potent, selective, LXR, inverse, agonist, liver, obesity, receptors, LXR-like, Receptors, 5854, Tocris Bioscience

1 Citation for SR 9238

Citations are publications that use Tocris products. Selected citations for SR 9238 include:

Bruschi et al (2019) PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells. Hepatol Commun 3 1191 PMID: 31497741

Do you know of a great paper that uses SR 9238 from Tocris? Please let us know.

Reviews for SR 9238

There are currently no reviews for this product. Be the first to review SR 9238 and earn rewards!

Have you used SR 9238?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors