SR 9009

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Description: Rev-Erbα/β agonist
Chemical Name: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for SR 9009

SR 9009 is a Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.

Compound Libraries for SR 9009

SR 9009 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 9009

M. Wt 437.94
Formula C20H24ClN3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1379686-30-2
PubChem ID 57394020
InChI Key MMJJNHOIVCGAAP-UHFFFAOYSA-N
Smiles ClC(C=C1)=CC=C1CN(CC2CCN(C(OCC)=O)C2)CC3=CC=C([N+]([O-])=O)S3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 9009

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.79 100
ethanol 43.79 100

Preparing Stock Solutions for SR 9009

The following data is based on the product molecular weight 437.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for SR 9009

References are publications that support the biological activity of the product.

Solt et al (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485 62 PMID: 22460951

Shin et al (2012) Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 22 4413 PMID: 22633688


If you know of a relevant reference for SR 9009, please let us know.

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Keywords: SR 9009, SR 9009 supplier, SR9009, Rev-Erbalpha, Rev-Erba, Rev-Erbbeta, Rev-Erbb, Rev-Erbα, Rev-Erbβ, agonists, agonism, circadian, rhythm, antiobesity, brain, penetrant, Rev-Erb, Receptors, 5855, Tocris Bioscience

1 Citation for SR 9009

Citations are publications that use Tocris products. Selected citations for SR 9009 include:

Hanne M et al (2022) Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia. Sci Rep 12 17856 PMID: 36284122


Do you know of a great paper that uses SR 9009 from Tocris? Please let us know.

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