SR 9009

Pricing Availability Delivery Time Qty
Cat.No. 5855 - SR 9009 | C20H24ClN3O4S | CAS No. 1379686-30-2
Description: Rev-Erbα/β agonist
Chemical Name: Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Purity: ≥98% (HPLC)

Biological Activity

Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.

Technical Data

M. Wt 437.94
Formula C20H24ClN3O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1379686-30-2
PubChem ID 57394020
Smiles ClC(C=C1)=CC=C1CN(CC2CCN(C(OCC)=O)C2)CC3=CC=C([N+]([O-])=O)S3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.79 100
ethanol 43.79 100

Preparing Stock Solutions

The following data is based on the product molecular weight 437.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Solt et al (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485 62 PMID: 22460951

Shin et al (2012) Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 22 4413 PMID: 2633688

If you know of a relevant reference for SR 9009, please let us know.

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View all Rev-Erb Receptor Agonists

Keywords: SR9009 Rev-Erbalpha Rev-Erba Rev-Erbbeta Rev-Erbb Rev-Erbα Rev-Erbβ agonists agonism circadian rhythm antiobesity brain penetrant Rev-Erb Receptors

Citations for SR 9009

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Literature in this Area

Nuclear Receptors

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Pathways for SR 9009


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