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SR 9009 is a Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.
SR 9009 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 437.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.42 mL||22.83 mL|
|5 mM||0.46 mL||2.28 mL||4.57 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the biological activity of the product.
Solt et al (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485 62 PMID: 22460951
Shin et al (2012) Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 22 4413 PMID: 22633688
If you know of a relevant reference for SR 9009, please let us know.
Keywords: SR 9009, SR 9009 supplier, SR9009, Rev-Erbalpha, Rev-Erba, Rev-Erbbeta, Rev-Erbb, Rev-Erbα, Rev-Erbβ, agonists, agonism, circadian, rhythm, antiobesity, brain, penetrant, Rev-Erb, Receptors, 5855, Tocris Bioscience
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