SR 7826

Pricing Availability Delivery Time Qty
Cat.No. 5626 - SR 7826 | C22H21N5O2 | CAS No. 1219728-20-7
Description: Potent and selective LIMK inhibitor; antitumor
Chemical Name: N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.

Technical Data

M. Wt 387.43
Formula C22H21N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1219728-20-7
PubChem ID 45381385
InChI Key WQAGVQVBDHOHRD-UHFFFAOYSA-N
Smiles O=C(N(CCO)C4=CC=CC=C4)NC(C=C3)=CC=C3C1=C2C(NC=C2C)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.74 100
ethanol 3.87 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 387.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.91 mL 25.81 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID: 25621531


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Citations for SR 7826

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Literature in this Area

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Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for SR 7826

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