SR 2211

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Cat.No. 4869 - SR 2211 | C26H24F7N3O | CAS No. 1359164-11-6
Description: Selective RORγ inverse agonist
Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries

SR 2211 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 527.48
Formula C26H24F7N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1359164-11-6
PubChem ID 51035449
InChI Key KVHKWAZUPPBMLL-UHFFFAOYSA-N
Smiles FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 26.37 50
DMSO 52.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 527.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672 PMID: 22292739


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View all Retinoic Acid-related Orphan Receptor Antagonists

Keywords: SR2211 inverse agonists retinoic acid receptor-related orphan receptor RORg RORgamma RORγ selective Retinoic Acid-related Orphan Receptors

Citations for SR 2211

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Literature in this Area

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for SR 2211

Protocols

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