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Selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.
Sold under license from The Scripps Research Institute.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 527.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.9 mL||9.48 mL||18.96 mL|
|5 mM||0.38 mL||1.9 mL||3.79 mL|
|10 mM||0.19 mL||0.95 mL||1.9 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the biological activity of the product.
Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672 PMID: 22292739
If you know of a relevant reference for SR 2211, please let us know.
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Keywords: SR 2211, SR 2211 supplier, SR2211, inverse, agonists, retinoic, acid, receptor-related, orphan, receptor, RORg, RORgamma, RORγ, selective, Retinoic, Acid-related, Orphan, Receptors, 4869, Tocris Bioscience
Citations for SR 2211
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