SR 2211

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Description: Selective RORγ inverse agonist
Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews

Biological Activity for SR 2211

SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries for SR 2211

SR 2211 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 2211

M. Wt 527.48
Formula C26H24F7N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1359164-11-6
PubChem ID 51035449
InChI Key KVHKWAZUPPBMLL-UHFFFAOYSA-N
Smiles FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 2211

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.75 100

Preparing Stock Solutions for SR 2211

The following data is based on the product molecular weight 527.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for SR 2211

Certificate of Analysis / Product Datasheet
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References for SR 2211

References are publications that support the biological activity of the product.

Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672 PMID: 22292739


If you know of a relevant reference for SR 2211, please let us know.

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Keywords: SR 2211, SR 2211 supplier, SR2211, inverse, agonists, retinoic, acid, receptor-related, orphan, receptor, RORg, RORgamma, RORγ, selective, Retinoic, Acid-related, Orphan, Receptors, 4869, Tocris Bioscience

3 Citations for SR 2211

Citations are publications that use Tocris products. Selected citations for SR 2211 include:

Brian T et al (2021) Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol 12 715059 PMID: 34408754

Hong-Wu et al (2021) Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling. Cancers (Basel) 13 PMID: 33916325

Peter D et al (2019) A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell 177 572-586.e22 PMID: 30955884


Do you know of a great paper that uses SR 2211 from Tocris? Please let us know.

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