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Submit ReviewSR 2211
Description: Selective RORγ inverse agonist
Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Purity: ≥98% (HPLC)
Biological Activity for SR 2211
SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.
Licensing Information
Sold under license from The Scripps Research Institute.
Compound Libraries for SR 2211
SR 2211 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SR 2211
| M. Wt | 527.48 |
| Formula | C26H24F7N3O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1359164-11-6 |
| PubChem ID | 51035449 |
| InChI Key | KVHKWAZUPPBMLL-UHFFFAOYSA-N |
| Smiles | FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 2211
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.75 | 100 |
Preparing Stock Solutions for SR 2211
The following data is based on the product molecular weight 527.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.9 mL | 9.48 mL | 18.96 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.79 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.9 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets for SR 2211
References for SR 2211
References are publications that support the biological activity of the product.
Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672 PMID: 22292739
If you know of a relevant reference for SR 2211, please let us know.
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Keywords: SR 2211, SR 2211 supplier, SR2211, inverse, agonists, retinoic, acid, receptor-related, orphan, receptor, RORg, RORgamma, RORγ, selective, Retinoic, Acid-related, Orphan, Receptors, 4869, Tocris Bioscience
3 Citations for SR 2211
Citations are publications that use Tocris products. Selected citations for SR 2211 include:
Peter D et al (2019) A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell 177 572-586.e22 PMID: 30955884
Brian T et al (2021) Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol 12 715059 PMID: 34408754
Hong-Wu et al (2021) Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling. Cancers (Basel) 13 PMID: 33916325
Do you know of a great paper that uses SR 2211 from Tocris? Please let us know.
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