SR 2211

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Cat.No. 4869 - SR 2211 | C26H24F7N3O | CAS No. 1359164-11-6
Description: Selective RORγ inverse agonist
Chemical Name: 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries

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Technical Data

M. Wt 527.48
Formula C26H24F7N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1359164-11-6
PubChem ID 51035449
InChI Key KVHKWAZUPPBMLL-UHFFFAOYSA-N
Smiles FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.75 100
1eq. HCl 26.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 527.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672 PMID: 22292739


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Keywords: SR 2211, SR 2211 supplier, SR2211, inverse, agonists, retinoic, acid, receptor-related, orphan, receptor, RORg, RORgamma, RORγ, selective, Retinoic, Acid-related, Orphan, Receptors, 4869, Tocris Bioscience

Citations for SR 2211

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Literature in this Area

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