SR 16584

Pricing Availability   Qty
Description: Selective α3β4 nAChR antagonist
Chemical Name: 1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for SR 16584

SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM). Selectively binds α3β4 over α4β2 and α7 subtypes (Ki values are 0.508, >100 and >100 μM, respectively).

Technical Data for SR 16584

M. Wt 270.37
Formula C17H22N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1150153-86-8
PubChem ID 42602880
Smiles O=C(CC3=C2C=CC=C3)N2[C@H]1C[C@@H](N4C)CCC[C@@H]4C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 16584

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.04 100

Preparing Stock Solutions for SR 16584

The following data is based on the product molecular weight 270.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.49 mL 36.99 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for SR 16584

Certificate of Analysis / Product Datasheet
Select another batch:

References for SR 16584

References are publications that support the biological activity of the product.

Zaveri et al (2012) Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J.Med.Chem. 53 8187 PMID: 20979364

If you know of a relevant reference for SR 16584, please let us know.

View Related Products by Product Action

View all Nicotinic Receptor (Other Subtype) Antagonists

Keywords: SR 16584, SR 16584 supplier, SR16584, nAChRs, nicotinic, acetylcholine, receptors, a3b4, alpha3beta4, α3β4, antagonists, Nicotinic, Receptors, (Other, Subtypes), 4424, Tocris Bioscience

Citations for SR 16584

Citations are publications that use Tocris products.

Currently there are no citations for SR 16584. Do you know of a great paper that uses SR 16584 from Tocris? Please let us know.

Reviews for SR 16584

There are currently no reviews for this product. Be the first to review SR 16584 and earn rewards!

Have you used SR 16584?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.