SR 0987

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Cat.No. 5868 - SR 0987 | C16H10ClF6NO2 | CAS No. 303126-97-8
Description: T cell-specific RORγ (RORγt) agonist
Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

Technical Data

M. Wt 397.7
Formula C16H10ClF6NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 303126-97-8
PubChem ID 2323435
InChI Key IZVBONMVWLTLNT-UHFFFAOYSA-N
Smiles OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C=C1)NC(C2=C(C=CC=C2)Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.77 100
ethanol 39.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 397.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.57 mL 25.14 mL
5 mM 0.5 mL 2.51 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012 PMID: 26785144


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