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Biological Activity for SR 0987
SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.
Compound Libraries for SR 0987
Technical Data for SR 0987
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 0987
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SR 0987
The following data is based on the product molecular weight 397.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.51 mL||12.57 mL||25.14 mL|
|5 mM||0.5 mL||2.51 mL||5.03 mL|
|10 mM||0.25 mL||1.26 mL||2.51 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References for SR 0987
References are publications that support the biological activity of the product.
Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012 PMID: 26785144
If you know of a relevant reference for SR 0987, please let us know.
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Keywords: SR 0987, SR 0987 supplier, SR0987, T-cell, specific, RORgamma, RORg, RORγ, agonists, agonism, cancer, immunity, antitumor, immunotherapy, immunology, Retinoic, Acid-related, Orphan, Receptors, 5868, Tocris Bioscience
Citations for SR 0987
Citations are publications that use Tocris products.
Currently there are no citations for SR 0987. Do you know of a great paper that uses SR 0987 from Tocris? Please let us know.
Reviews for SR 0987
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Literature in this Area
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