SR 0987

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Description: T cell-specific RORγ (RORγt) agonist
Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Purity: ≥98% (HPLC)

Biological Activity for SR 0987

SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

Compound Libraries for SR 0987

SR 0987 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 0987

M. Wt 397.7
Formula C16H10ClF6NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 303126-97-8
PubChem ID 2323435
Smiles OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C=C1)NC(C2=C(C=CC=C2)Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 0987

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.77 100
ethanol 39.77 100

Preparing Stock Solutions for SR 0987

The following data is based on the product molecular weight 397.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.57 mL 25.14 mL
5 mM 0.5 mL 2.51 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for SR 0987

References are publications that support the biological activity of the product.

Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012 PMID: 26785144

If you know of a relevant reference for SR 0987, please let us know.

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Citations for SR 0987

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