Splitomicin

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Cat.No. 1542 - Splitomicin | C13H10O2 | CAS No. 5690-03-9
Description: Sir2p inhibitor
Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Compound Libraries

Splitomicin is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 198.22
Formula C13H10O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 5690-03-9
PubChem ID 5269
InChI Key ISFPDBUKMJDAJH-UHFFFAOYSA-N
Smiles O=C1CCC2=C(O1)C=CC1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.82 100
ethanol 19.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 198.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.04 mL 25.22 mL 50.45 mL
5 mM 1.01 mL 5.04 mL 10.09 mL
10 mM 0.5 mL 2.52 mL 5.04 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bedalov et al (2001) Identification of a small molecule inhibitor of Sir2p. Proc.Natl.Acad.Sci.U.S.A. 98 15113 PMID: 11752457


If you know of a relevant reference for Splitomicin, please let us know.

View Related Products by Product Action

View all Class III HDAC (Sirtuin) Inhibitors

Keywords: Splitomicin, Splitomicin supplier, Sir2p, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Class, III, HDACs, (Sirtuins), 1542, Tocris Bioscience

2 Citations for Splitomicin

Citations are publications that use Tocris products. Selected citations for Splitomicin include:

Kumari and Usdin (2014) Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription. Hum Mol Genet 23 6575 PMID: 25055869

Stavrou et al (2015) Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. J Neurosci 125 710 PMID: 25339356


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Literature in this Area

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