Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 198.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.04 mL||25.22 mL||50.45 mL|
|5 mM||1.01 mL||5.04 mL||10.09 mL|
|10 mM||0.5 mL||2.52 mL||5.04 mL|
|50 mM||0.1 mL||0.5 mL||1.01 mL|
References are publications that support the products' biological activity.
Bedalov et al (2001) Identification of a small molecule inhibitor of Sir2p. Proc.Natl.Acad.Sci.U.S.A. 98 15113 PMID: 11752457
If you know of a relevant reference for Splitomicin, please let us know.
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Keywords: Splitomicin, supplier, Sir2p, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Sir2-like, Family, Deacetylases, Sir2-like, Family, Deacetylases, Tocris Bioscience
2 Citations for Splitomicin
Citations are publications that use Tocris products. Selected citations for Splitomicin include:
Stavrou et al (2015) Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. J Neurosci 125 710 PMID: 25339356
Kumari and Usdin (2014) Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription. Hum Mol Genet 23 6575 PMID: 25055869
Do you know of a great paper that uses Splitomicin from Tocris? If so please let us know.
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