Discontinued Product

Spiroxatrine (Cat. No. 0631) has been withdrawn from sale for commercial reasons.
Description: Potent α2C antagonist
Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Citations (1)
Literature (2)

Biological Activity for Spiroxatrine

Spiroxatrine is a 5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.

Technical Data for Spiroxatrine

M. Wt 379.46
Formula C22H25N3O3
Storage Store at RT
CAS Number 1054-88-2
PubChem ID 5268

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Spiroxatrine

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for Spiroxatrine

References are publications that support the biological activity of the product.

Bylund et al (1992) Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol.Pharmacol. 42 1 PMID: 1353247

Nelson and Taylor (1986) Spiroxatrine: a selective serotonin 1A receptor antagonist. Eur.J.Pharmacol. 124 207 PMID: 3720840

Schoeffter and Hoyer (1988) Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br.J.Pharmacol. 95 975 PMID: 3207999

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Keywords: Spiroxatrine, Spiroxatrine supplier, Potent, α2C-adrenoceptor, alpha2C-adrenoceptor, alpah2c-adrenergic, a2c-adrenoceptor, a2c-adrenergic, antagonists, 5-HT1A, Receptors, Serotonin, Adrenergic, Alpha-2, 0631, Tocris Bioscience

1 Citation for Spiroxatrine

Citations are publications that use Tocris products. Selected citations for Spiroxatrine include:

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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