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Submit ReviewSpiroxatrine
Discontinued Product
Spiroxatrine (Cat. No. 0631) has been withdrawn from sale for commercial reasons.
Description: Potent α2C antagonist
Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Biological Activity for Spiroxatrine
Spiroxatrine is a 5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.
Technical Data for Spiroxatrine
| M. Wt | 379.46 |
| Formula | C22H25N3O3 |
| Storage | Store at RT |
| CAS Number | 1054-88-2 |
| PubChem ID | 5268 |
| InChI Key | JVGBTTIJPBFLTE-UHFFFAOYSA-N |
| Smiles | O=C1NCN(C2=CC=CC=C2)C11CCN(CC2COC3=CC=CC=C3O2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Spiroxatrine
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
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References for Spiroxatrine
References are publications that support the biological activity of the product.
Bylund et al (1992) Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol.Pharmacol. 42 1 PMID: 1353247
Nelson and Taylor (1986) Spiroxatrine: a selective serotonin 1A receptor antagonist. Eur.J.Pharmacol. 124 207 PMID: 3720840
Schoeffter and Hoyer (1988) Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br.J.Pharmacol. 95 975 PMID: 3207999
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Keywords: Spiroxatrine, Spiroxatrine supplier, Potent, α2C-adrenoceptor, alpha2C-adrenoceptor, alpah2c-adrenergic, a2c-adrenoceptor, a2c-adrenergic, antagonists, 5-HT1A, Receptors, Serotonin, Adrenergic, Alpha-2, 0631, Tocris Bioscience
1 Citation for Spiroxatrine
Citations are publications that use Tocris products. Selected citations for Spiroxatrine include:
Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569
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