Spiroxatrine

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Cat.No. 0631 - Spiroxatrine | C22H25N3O3 | CAS No. 1054-88-2
Description: Potent α2C antagonist
Chemical Name: 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Datasheet
Citations (1)
Literature

Biological Activity

5-HT1A antagonist. More active and selective than spiperone. Also a very potent α2C adrenergic receptor antagonist.

Technical Data

M. Wt 379.46
Formula C22H25N3O3
Storage Store at RT
CAS Number 1054-88-2
PubChem ID 5268
InChI Key JVGBTTIJPBFLTE-UHFFFAOYSA-N
Smiles O=C1NCN(C2=CC=CC=C2)C11CCN(CC2COC3=CC=CC=C3O2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.79 10

Preparing Stock Solutions

The following data is based on the product molecular weight 379.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Bylund et al (1992) Pharmacological characteristics of α2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol.Pharmacol. 42 1 PMID: 1353247

Nelson and Taylor (1986) Spiroxatrine: a selective serotonin 1A receptor antagonist. Eur.J.Pharmacol. 124 207 PMID: 3720840

Schoeffter and Hoyer (1988) Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br.J.Pharmacol. 95 975 PMID: 3207999


If you know of a relevant reference for Spiroxatrine, please let us know.

View Related Products by Product Action

View all Adrenergic α2 Receptor Antagonists

Keywords: Spiroxatrine, supplier, Potent, α2C-adrenoceptor, alpha2C-adrenoceptor, alpah2c-adrenergic, a2c-adrenoceptor, a2c-adrenergic, antagonists, 5-HT1A, Receptors, Serotonin, Adrenergic, Alpha-2, Receptors, Tocris Bioscience

1 Citation for Spiroxatrine

Citations are publications that use Tocris products. Selected citations for Spiroxatrine include:

Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569


Do you know of a great paper that uses Spiroxatrine from Tocris? If so please let us know.

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