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Submit ReviewSpermine NONOate
Description: Slow NO releasing agent
Chemical Name: N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl-1,3-propanediamine
Biological Activity for Spermine NONOate
A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution).
Licensing Information
Sold with the permission of the NIH, US Patent 5,155,137
Technical Data for Spermine NONOate
| M. Wt | 262.35 |
| Formula | C10H26N6O2 |
| Storage | Desiccate at -20°C |
| CAS Number | 136587-13-8 |
| PubChem ID | 5259 |
| InChI Key | QPIOUFBAROSIAN-UHFFFAOYSA-N |
| Smiles | NCCCN(N(O)N=O)CCCCNCCCN |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Spermine NONOate
References for Spermine NONOate
References are publications that support the biological activity of the product.
Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570
Homer and Wanstall (1998) In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur.J.Pharmacol. 356 49 PMID: 9761423
Maragos et al (1991) Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J.Med.Chem. 34 3242 PMID: 1956043
Ramamurthi and Lewis (1997) Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem.Res.Toxicol. 10 408 PMID: 9114977
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Keywords: Spermine NONOate, Spermine NONOate supplier, Slow, NO, releasing, agent, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, /, 1135, Tocris Bioscience
1 Citation for Spermine NONOate
Citations are publications that use Tocris products. Selected citations for Spermine NONOate include:
Russell et al (2013) Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range. FEBS J 280 6070 PMID: 24034856
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