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SNDX-5613

Cat. No. 8907 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Menin-MLL interaction inhibitor
Alternative Names: Revumenib
Chemical Name: N-Ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SNDX-5613

SNDX-5613 is a potent inhibitor of menin-MLL1 protein-protein interaction (Ki = 0.149 nM; IC50 = 10-20 nM). Induces promising antileukaemic activity leading to deep and sustained remission in patients with highly refractory acute leukaemia with KMT2Ar or NPM1 mutation.

Technical Data for SNDX-5613

M. Wt 630.82
Formula C32H47FN6O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2169919-21-3
PubChem ID 132212657
InChI Key FRVSRBKUQZKTOW-YOCNBXQISA-N
Smiles CC(N(C(C1=CC(F)=CC=C1OC2=C(N=CN=C2)N3CC4(C3)CCN(CC4)C[C@@H]5CC[C@H](CC5)NS(CC)(=O)=O)=O)CC)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNDX-5613

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.54 50
ethanol 12.62 20

Preparing Stock Solutions for SNDX-5613

The following data is based on the product molecular weight 630.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.17 mL 15.85 mL 31.7 mL
2.5 mM 0.63 mL 3.17 mL 6.34 mL
5 mM 0.32 mL 1.59 mL 3.17 mL
25 mM 0.06 mL 0.32 mL 0.63 mL

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References for SNDX-5613

References are publications that support the biological activity of the product.

Fiskus et al (2023) Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1. Blood Cancer J. 13 PMID: 37055414

Issa et al (2023) The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia. Nature 615 920 PMID: 36922593

Perner et al (2023) MEN1 mutations mediate clinical resistance to menin inhibition. 615 913 PMID: 36922589

If you know of a relevant reference for SNDX-5613, please let us know.

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Keywords: SNDX-5613, SNDX-5613 supplier, Revumenib, SNDX-5613, SNDC, 5613, potent, inhibitor, inhibits, protein, interaction, PPI, Menin, MEN1, MLL1, lysine, methyltransferase, refractory, acute, leukaemia, KMT2A, NPM1, mutation, Other, Lysine, Methyltransferases, 8907, Tocris Bioscience

Citations for SNDX-5613

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