SNAP 5089

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Cat.No. 2398 - SNAP 5089 | C36H40N4O5.HCl | CAS No. 157066-77-8
Description: Subtype-selective α1A antagonist
Chemical Name: 5-[[[3-(4,4-Diphenyl-1-piperidinyl)propyl]amino]carbonyl]-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-pyridinecarboxylic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Subtype-selective α1A-adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (Kivalues are 0.35, 220, 370, 540, 800 and 1200 nM for α1A, α1B, α2C, α1D, α2B and α2A subtypes respectively and 540 nM for L-type Ca2+ channels). Inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues.

Technical Data

M. Wt 645.19
Formula C36H40N4O5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 157066-77-8
PubChem ID 56972175
InChI Key MXELDPKESKXREN-UHFFFAOYSA-N
Smiles CC1=C(C(OC)=O)C(C2=CC=C([N+]([O-])=O)C=C2)C(C(NCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)=C(C)N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 64.52 100
ethanol 64.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 645.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.55 mL 7.75 mL 15.5 mL
5 mM 0.31 mL 1.55 mL 3.1 mL
10 mM 0.15 mL 0.77 mL 1.55 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wetzel et al (1995) Discovery of α1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182

Leonardi et al (1997) Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15-2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, Part I. J.Pharmacol.Exp.Ther. 281 1272 PMID: 9190863

Kava et al (1998) α1L-adrenceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol. 123 1359 PMID: 9579731


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Keywords: Subtype selective α1A-adrenoceptor alpha1A-adrenoceptors a1a-adrenoceptors α1a-adrenergic alpha1a-adrenergic a1a-adrenergic antagonists Receptors SNAP5089 Adrenergic Alpha-1 Receptors

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