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Description: Selective non-lipid inhibitor of sphingosine kinase
Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Purity: ≥98% (HPLC)
Citations (6)

Biological Activity for SKI II

SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).

Technical Data for SKI II

M. Wt 302.78
Formula C15H11ClN2OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 312636-16-1
PubChem ID 753704
Smiles OC1=CC=C(NC2=NC(=CS2)C2=CC=C(Cl)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SKI II

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.28 100

Preparing Stock Solutions for SKI II

The following data is based on the product molecular weight 302.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.51 mL 33.03 mL
5 mM 0.66 mL 3.3 mL 6.61 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets for SKI II

Certificate of Analysis / Product Datasheet
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References for SKI II

References are publications that support the biological activity of the product.

French et al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596 PMID: 16632640

French et al (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63 5862

If you know of a relevant reference for SKI II, please let us know.

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Keywords: SKI II, SKI II supplier, Selective, non-lipid, inhibitors, inhibits, sphingosine, kinases, antitumor, Lipid, Metabolism, sphingosine-1-phosphate, S1P, SKIII, sphk, Sphingosine, Kinase, 2097, Tocris Bioscience

6 Citations for SKI II

Citations are publications that use Tocris products. Selected citations for SKI II include:

Reid et al (2015) Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex. Am J Nephrol 4 e61 PMID: 26576339

Seong et al (2017) A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res 77 696 PMID: 27899382

Xun et al (2015) Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. J Exp Clin Cancer Res 34 94 PMID: 26337959

Minashima et al (2014) The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes. Osteoarthritis Cartilage 22 852 PMID: 24747173

Do you know of a great paper that uses SKI II from Tocris? Please let us know.

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