Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 302.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.3 mL||16.51 mL||33.03 mL|
|5 mM||0.66 mL||3.3 mL||6.61 mL|
|10 mM||0.33 mL||1.65 mL||3.3 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References are publications that support the products' biological activity.
French et al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596 PMID: 16632640
If you know of a relevant reference for SKI II, please let us know.
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Keywords: SKI II, supplier, Selective, non-lipid, inhibitors, inhibits, sphingosine, kinases, antitumor, Lipid, Metabolism, sphingosine-1-phosphate, S1P, SKIII, sphk, Sphingosine, Kinase, Sphingosine, Kinase, Tocris Bioscience
4 Citations for SKI II
Citations are publications that use Tocris products. Selected citations for SKI II include:
Kim et al (2010) Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. J Biol Chem 31 353 PMID: 20234131
Reid et al (2015) Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex. Am J Nephrol 4 e61 PMID: 26576339
Park et al (2012) A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 303 F721 PMID: 22759398
Xun et al (2015) Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. J Exp Clin Cancer Res 34 94 PMID: 26337959
Do you know of a great paper that uses SKI II from Tocris? If so please let us know.
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Literature in this Area
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