SKI II

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Cat.No. 2097 - SKI II | C15H11ClN2OS | CAS No. 312636-16-1
Description: Selective non-lipid inhibitor of sphingosine kinase
Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).

Technical Data

M. Wt 302.78
Formula C15H11ClN2OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 312636-16-1
PubChem ID 753704
InChI Key ZFGXZJKLOFCECI-UHFFFAOYSA-N
Smiles OC1=CC=C(NC2=NC(=CS2)C2=CC=C(Cl)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 302.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.51 mL 33.03 mL
5 mM 0.66 mL 3.3 mL 6.61 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

French et al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596 PMID: 16632640

French et al (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63 5862


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Keywords: SKI II, SKI II supplier, Selective, non-lipid, inhibitors, inhibits, sphingosine, kinases, antitumor, Lipid, Metabolism, sphingosine-1-phosphate, S1P, SKIII, sphk, Sphingosine, Kinase, 2097, Tocris Bioscience

5 Citations for SKI II

Citations are publications that use Tocris products. Selected citations for SKI II include:

Park et al (2012) A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 303 F721 PMID: 22759398

Xun et al (2015) Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. J Exp Clin Cancer Res 34 94 PMID: 26337959

Kim et al (2010) Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. J Biol Chem 31 353 PMID: 20234131

Reid et al (2015) Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex. Am J Nephrol 4 e61 PMID: 26576339

Minashima et al (2014) The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes. Osteoarthritis Cartilage 22 852 PMID: 24747173


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Literature in this Area

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