SJ 172550

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Cat.No. 3929 - SJ 172550 | C22H21ClN2O5 | CAS No. 431979-47-4
Description: MDMX inhibitor. Disrupts MDMX-p53 interaction
Chemical Name: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]acetic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.

Compound Libraries

SJ 172550 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 428.87
Formula C22H21ClN2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 431979-47-4
PubChem ID 1317464
InChI Key RKKFQJXGAQWHBZ-LICLKQGHSA-N
Smiles O=C(N(C3=CC=CC=C3)N=C2C)/C2=C/C1=CC(OCC)=C(OCC(OC)=O)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.89 100

Preparing Stock Solutions

The following data is based on the product molecular weight 428.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.32 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Reed et al (2010) Identification and characterization of the first small molecule inhibitor of MDMX. J.Biol.Chem. 285 10786 PMID: 20080970


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View all p53 Activators

Keywords: disrupts p53 MDMX interaction inhibitors inhibits SJ172550 NHPP-spermine p53

Citations for SJ 172550

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for SJ 172550

p53

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.

Protocols

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