MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 428.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.33 mL||11.66 mL||23.32 mL|
|5 mM||0.47 mL||2.33 mL||4.66 mL|
|10 mM||0.23 mL||1.17 mL||2.33 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
Reed et al (2010) Identification and characterization of the first small molecule inhibitor of MDMX. J.Biol.Chem. 285 10786 PMID: 20080970
If you know of a relevant reference for SJ 172550, please let us know.
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Keywords: SJ 172550, SJ 172550 supplier, disrupts, p53, MDMX, interaction, inhibitors, inhibits, SJ172550, NHPP-spermine, 3929, Tocris Bioscience
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Cell Cycle & DNA Damage Repair Poster
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