SJ 172550

Pricing Availability Delivery Time Qty
Cat.No. 3929 - SJ 172550 | C22H21ClN2O5 | CAS No. 431979-47-4
Description: MDMX inhibitor. Disrupts MDMX-p53 interaction
Chemical Name: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]acetic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.

Compound Libraries

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Technical Data

M. Wt 428.87
Formula C22H21ClN2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 431979-47-4
PubChem ID 1317464
InChI Key RKKFQJXGAQWHBZ-LICLKQGHSA-N
Smiles O=C(N(C3=CC=CC=C3)N=C2C)/C2=C/C1=CC(OCC)=C(OCC(OC)=O)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.89 100

Preparing Stock Solutions

The following data is based on the product molecular weight 428.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.32 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Reed et al (2010) Identification and characterization of the first small molecule inhibitor of MDMX. J.Biol.Chem. 285 10786 PMID: 20080970


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Keywords: SJ 172550, supplier, disrupts, p53, MDMX, interaction, inhibitors, inhibits, SJ172550, NHPP-spermine, p53, p53, Tocris Bioscience

Citations for SJ 172550

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for SJ 172550

p53

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.