SIS17

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Description: Selective HDAC11 inhibitor
Chemical Name: N'-Hexadecylthiophene-2-carbohydrazide
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for SIS17

SIS17 is a selective HDAC11 inhibitor (IC50 = 0.83 μM). Inhibits demyristoylation of serine hydroxymethyl transferase 2 with no detectable activity at other HDAC subtypes. Combination with Oxaliplatin (Cat. No. 2623) increases cytotoxicity to K562 cells; improves survival of Oxaliplatin-treated 769P cells. Cell permeable.

Technical Data for SIS17

M. Wt 366.61
Formula C21H38N2OS
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2374313-54-7
PubChem ID 139035087
InChI Key HSHXDCVZWHOWCS-UHFFFAOYSA-N
Smiles O=C(NNCCCCCCCCCCCCCCCC)C=1SC=CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SIS17

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.67 10

Preparing Stock Solutions for SIS17

The following data is based on the product molecular weight 366.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.28 mL 136.38 mL 272.77 mL
0.5 mM 5.46 mL 27.28 mL 54.55 mL
1 mM 2.73 mL 13.64 mL 27.28 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

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References for SIS17

References are publications that support the biological activity of the product.

Son et al (2019) Activity-guided design of HDAC11-specific inhibitors. ACS Chem.Biol. 14 1393 PMID: 31264832

Li et al (2022) A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 36 e22326 PMID: 35657209


If you know of a relevant reference for SIS17, please let us know.

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Keywords: SIS17, SIS17 supplier, SIS17, HDAC, HDAC11, inhibitors, inhibit, inhibits, selective, cytotoxicity, Class, IV, HDACs, 7969, Tocris Bioscience

Citations for SIS17

Citations are publications that use Tocris products.

Currently there are no citations for SIS17. Do you know of a great paper that uses SIS17 from Tocris? Please let us know.

Reviews for SIS17

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.