Sirtinol

Pricing Availability   Qty
Description: Selective sirtuin family deacetylase inhibitor
Chemical Name: 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (1)

Biological Activity for Sirtinol

Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

Technical Data for Sirtinol

M. Wt 394.47
Formula C26H22N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 410536-97-9
PubChem ID 5717148
InChI Key YUGODMKHHCZZOI-QJOMJCCJSA-N
Smiles O=C(NC(C)C3=CC=CC=C3)C1=CC=CC=C1/N=C/C2=C(C=CC=C4)C4=CC=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sirtinol

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.45 100

Preparing Stock Solutions for Sirtinol

The following data is based on the product molecular weight 394.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References for Sirtinol

References are publications that support the biological activity of the product.

Grozinger et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 276 38837 PMID: 11483616

Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789 PMID: 16302818

Kahyo et al (2008) A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 108 364 PMID: 19008647

Jung-Hynes et al (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 284 3823 PMID: 19075016


If you know of a relevant reference for Sirtinol, please let us know.

View Related Products by Product Action

View all Class III HDAC (Sirtuin) Inhibitors

Keywords: Sirtinol, Sirtinol supplier, Selective, sirtuin, family, deacetylases, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Class, III, HDACs, (Sirtuins), 3521, Tocris Bioscience

6 Citations for Sirtinol

Citations are publications that use Tocris products. Selected citations for Sirtinol include:

Paffett et al (2011) Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vascul Pharmacol 56 64 PMID: 22146233

Kirby D et al (2012) Activation of the stress proteome as a mechanism for small molecule therapeutics. Hum Mol Genet 21 4237-52 PMID: 22752410

María J et al (2011) The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin. Diabetes 60 1177-85 PMID: 21386086

Stoney et al (2016) Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes. Glia 64 425 PMID: 26527258


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Literature in this Area

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