Sirtinol

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Cat.No. 3521 - Sirtinol | C26H22N2O2 | CAS No. 410536-97-9
Description: Selective sirtuin family deacetylase inhibitor
Chemical Name: 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

Compound Libraries

Sirtinol is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 394.47
Formula C26H22N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 410536-97-9
PubChem ID 5717148
InChI Key YUGODMKHHCZZOI-QJOMJCCJSA-N
Smiles O=C(NC(C)C3=CC=CC=C3)C1=CC=CC=C1/N=C/C2=C(C=CC=C4)C4=CC=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Grozinger et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 276 38837 PMID: 11483616

Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789 PMID: 16302818

Kahyo et al (2008) A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 108 364 PMID: 19008647

Jung-Hynes et al (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 284 3823 PMID: 19075016


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View Related Products by Product Action

View all Class III HDAC (Sirtuin) Inhibitors

Keywords: Sirtinol, Sirtinol supplier, Selective, sirtuin, family, deacetylases, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Class, III, HDACs, (Sirtuins), 3521, Tocris Bioscience

3 Citations for Sirtinol

Citations are publications that use Tocris products. Selected citations for Sirtinol include:

Stoney et al (2016) Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes. Glia 64 425 PMID: 26527258

Balaiya et al (2012) Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α. Mol Vis 18 114 PMID: 22275802

Paffett et al (2011) Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vascul Pharmacol 56 64 PMID: 22146233


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Literature in this Area

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