SirReal 2

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Cat.No. 5457 - SirReal 2 | C22H20N4OS2 | CAS No. 709002-46-0
Description: Selective inhibitor of SIRT2
Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.

Compound Libraries

SirReal 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 420.55
Formula C22H20N4OS2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 709002-46-0
PubChem ID 1096292
InChI Key MENNDDDTIIZDDN-UHFFFAOYSA-N
Smiles CC1=CC(C)=NC(SCC(NC2=NC=C(CC3=CC=CC4=C3C=CC=C4)S2)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 420.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Rumpf et al (2015) Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 6 6263 PMID: 25672491


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Keywords: SirReal 2, SirReal 2 supplier, SirReal2, selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Class, III, HDACs, (Sirtuins), 5457, Tocris Bioscience

Citations for SirReal 2

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Literature in this Area

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