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Biological Activity for SirReal 2
SirReal 2 is a selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.
Compound Libraries for SirReal 2
Technical Data for SirReal 2
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SirReal 2
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SirReal 2
The following data is based on the product molecular weight 420.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.38 mL||11.89 mL||23.78 mL|
|5 mM||0.48 mL||2.38 mL||4.76 mL|
|10 mM||0.24 mL||1.19 mL||2.38 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for SirReal 2
References are publications that support the biological activity of the product.
Rumpf et al (2015) Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 6 6263 PMID: 25672491
If you know of a relevant reference for SirReal 2, please let us know.
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Keywords: SirReal 2, SirReal 2 supplier, SirReal2, selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Class, III, HDACs, (Sirtuins), 5457, Tocris Bioscience
Citations for SirReal 2
Citations are publications that use Tocris products.
Currently there are no citations for SirReal 2. Do you know of a great paper that uses SirReal 2 from Tocris? Please let us know.
Reviews for SirReal 2
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Literature in this Area
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