SIB 1553A hydrochloride

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Cat.No. 4764 - SIB 1553A hydrochloride | C13H19NOS.HCl | CAS No. 191611-89-9
Description: Subunit selective nAChR agonist
Chemical Name: (±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Nicotinic acetylcholine receptor (nAChR) agonist. Displays selectivity for β4 subunit-containing receptors. Stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes. Improves attention deficits and memory performance in a Parkinson's disease model.

Technical Data

M. Wt 273.82
Formula C13H19NOS.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 191611-89-9
PubChem ID 9881989
InChI Key RJSVKPQKXSMZMT-UHFFFAOYSA-N
Smiles CN1CCCC1CCSC2=CC=C(O)C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 273.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.26 mL 36.52 mL
5 mM 0.73 mL 3.65 mL 7.3 mL
10 mM 0.37 mL 1.83 mL 3.65 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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References

References are publications that support the biological activity of the product.

Vernier et al (1999) 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 42 1684 PMID: 10346920

Rao et al (2003) In vitro pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 981 85 PMID: 12885429

Schneider et al (2003) The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys. J.Pharmacol.Exp.Ther. 306 401 PMID: 12721323


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Literature in this Area

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