SIB 1553A hydrochloride

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Cat.No. 4764 - SIB 1553A hydrochloride | C13H19NOS.HCl | CAS No. 191611-89-9
Description: nAChR agonist; displays selectivity for β4 subunit-containing receptors
Chemical Name: (±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for SIB 1553A hydrochloride

SIB 1553A hydrochloride is a nicotinic acetylcholine receptor (nAChR) agonist. Displays selectivity for β4 subunit-containing receptors. Stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes. Improves attention deficits and memory performance in a Parkinson's disease model.

Technical Data for SIB 1553A hydrochloride

M. Wt 273.82
Formula C13H19NOS.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 191611-89-9
PubChem ID 9881989

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SIB 1553A hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 27.38 100

Preparing Stock Solutions for SIB 1553A hydrochloride

The following data is based on the product molecular weight 273.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.26 mL 36.52 mL
5 mM 0.73 mL 3.65 mL 7.3 mL
10 mM 0.37 mL 1.83 mL 3.65 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets for SIB 1553A hydrochloride

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Citations for SIB 1553A hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.