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Submit ReviewSIB 1553A hydrochloride
Description: nAChR agonist; displays selectivity for β4 subunit-containing receptors
Chemical Name: (±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Nicotinic acetylcholine receptor (nAChR) agonist. Displays selectivity for β4 subunit-containing receptors. Stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes. Improves attention deficits and memory performance in a Parkinson's disease model.
Technical Data
| M. Wt | 273.82 |
| Formula | C13H19NOS.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 191611-89-9 |
| PubChem ID | 9881989 |
| InChI Key | RJSVKPQKXSMZMT-UHFFFAOYSA-N |
| Smiles | CN1CCCC1CCSC2=CC=C(O)C=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.38 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 273.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.26 mL | 36.52 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.3 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Vernier et al (1999) 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 42 1684 PMID: 10346920
Rao et al (2003) In vitro pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 981 85 PMID: 12885429
Schneider et al (2003) The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys. J.Pharmacol.Exp.Ther. 306 401 PMID: 12721323
If you know of a relevant reference for SIB 1553A hydrochloride, please let us know.
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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