You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
SIB 1553A hydrochloride
Nicotinic acetylcholine receptor (nAChR) agonist. Displays selectivity for β4 subunit-containing receptors. Stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes. Improves attention deficits and memory performance in a Parkinson's disease model.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 273.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.65 mL||18.26 mL||36.52 mL|
|5 mM||0.73 mL||3.65 mL||7.3 mL|
|10 mM||0.37 mL||1.83 mL||3.65 mL|
|50 mM||0.07 mL||0.37 mL||0.73 mL|
References are publications that support the biological activity of the product.
Vernier et al (1999) 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 42 1684 PMID: 10346920
Rao et al (2003) In vitro pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 981 85 PMID: 12885429
Schneider et al (2003) The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys. J.Pharmacol.Exp.Ther. 306 401 PMID: 12721323
If you know of a relevant reference for SIB 1553A hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SIB 1553A hydrochloride, SIB 1553A hydrochloride supplier, SIB1553A, hydrochloride, SIB, 1553A, HCl, Nicotinic, acetylcholine, receptors, nAChR, agonist, cognitive, memory, Parkinson's, Alzheimer's, diseases, Receptors, (Other, Subtypes), 4764, Tocris Bioscience
Citations for SIB 1553A hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for SIB 1553A hydrochloride. Do you know of a great paper that uses SIB 1553A hydrochloride from Tocris? Please let us know.
Reviews for SIB 1553A hydrochloride
There are currently no reviews for this product. Be the first to review SIB 1553A hydrochloride and earn rewards!
Have you used SIB 1553A hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.