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Submit ReviewSIB 1553A hydrochloride
Discontinued Product
4764 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
Description: nAChR agonist; displays selectivity for β4 subunit-containing receptors
Chemical Name: (±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SIB 1553A hydrochloride
SIB 1553A hydrochloride is a nicotinic acetylcholine receptor (nAChR) agonist. Displays selectivity for β4 subunit-containing receptors. Stimulates acetylcholine levels and other neurotransmitters relevant for cognitive processes. Improves attention deficits and memory performance in a Parkinson's disease model.
Technical Data for SIB 1553A hydrochloride
| M. Wt | 273.82 |
| Formula | C13H19NOS.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 191611-89-9 |
| PubChem ID | 9881989 |
| InChI Key | RJSVKPQKXSMZMT-UHFFFAOYSA-N |
| Smiles | CN1CCCC1CCSC2=CC=C(O)C=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SIB 1553A hydrochloride
References for SIB 1553A hydrochloride
References are publications that support the biological activity of the product.
Vernier et al (1999) 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 42 1684 PMID: 10346920
Rao et al (2003) In vitro pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a nicotinic acetylcholine receptor ligand. Brain Res. 981 85 PMID: 12885429
Schneider et al (2003) The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys. J.Pharmacol.Exp.Ther. 306 401 PMID: 12721323
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Citations for SIB 1553A hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.