SI-2 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 5964 - SI-2 hydrochloride | C15H15N5.HCl
Description: Steroid receptor coactivator 3 (SRC-3) inhibitor
Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Technical Data

M. Wt 301.78
Formula C15H15N5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 121513909
InChI Key CDYJHORKRVKALB-NWBUNABESA-N
Smiles CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.04 20
water 15.09 50

Preparing Stock Solutions

The following data is based on the product molecular weight 301.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.57 mL 33.14 mL
5 mM 0.66 mL 3.31 mL 6.63 mL
10 mM 0.33 mL 1.66 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID: 7084884


If you know of a relevant reference for SI-2 hydrochloride, please let us know.

Keywords: steroid receptor coactivator-3 SRC3 inhibitors inhibits breast cancers orally available 223788-33-8 Other Nuclear Receptors

Citations for SI-2 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for SI-2 hydrochloride. Do you know of a great paper that uses SI-2 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for SI-2 hydrochloride

Protocols

TODO: Add Protocols