Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 301.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.63 mL||33.14 mL||66.27 mL|
|2.5 mM||1.33 mL||6.63 mL||13.25 mL|
|5 mM||0.66 mL||3.31 mL||6.63 mL|
|25 mM||0.13 mL||0.66 mL||1.33 mL|
References are publications that support the biological activity of the product.
Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID: 27084884
If you know of a relevant reference for SI-2 hydrochloride, please let us know.
Keywords: SI-2 hydrochloride, SI-2 hydrochloride supplier, steroid, receptor, coactivator-3, SRC3, inhibitors, inhibits, breast, cancers, orally, available, 223788-33-8, Other, Nuclear, Receptors, Histone, Acetyltransferases, Transcription, Factors, 5964, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for SI-2 hydrochloride. Do you know of a great paper that uses SI-2 hydrochloride from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review SI-2 hydrochloride and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.