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Submit ReviewSI-2 hydrochloride
Description: Steroid receptor coactivator 3 (SRC-3) inhibitor
Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SI-2 hydrochloride
SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
Technical Data for SI-2 hydrochloride
| M. Wt | 301.78 |
| Formula | C15H15N5.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1992052-49-9 |
| PubChem ID | 121513909 |
| InChI Key | CDYJHORKRVKALB-NWBUNABESA-N |
| Smiles | CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SI-2 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.09 | 50 | |
| DMSO | 6.04 | 20 |
Preparing Stock Solutions for SI-2 hydrochloride
The following data is based on the product molecular weight 301.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.63 mL | 33.14 mL | 66.27 mL |
| 2.5 mM | 1.33 mL | 6.63 mL | 13.25 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.63 mL |
| 25 mM | 0.13 mL | 0.66 mL | 1.33 mL |
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Product Datasheets for SI-2 hydrochloride
References for SI-2 hydrochloride
References are publications that support the biological activity of the product.
Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID: 27084884
If you know of a relevant reference for SI-2 hydrochloride, please let us know.
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1 Citation for SI-2 hydrochloride
Citations are publications that use Tocris products. Selected citations for SI-2 hydrochloride include:
Wei et al (2021) SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning. J Biol Chem 297 101044 PMID: 34358562
Do you know of a great paper that uses SI-2 hydrochloride from Tocris? Please let us know.
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