You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for SI-2 hydrochloride
SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.
Technical Data for SI-2 hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SI-2 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SI-2 hydrochloride
The following data is based on the product molecular weight 301.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.63 mL||33.14 mL||66.27 mL|
|2.5 mM||1.33 mL||6.63 mL||13.25 mL|
|5 mM||0.66 mL||3.31 mL||6.63 mL|
|25 mM||0.13 mL||0.66 mL||1.33 mL|
Product Datasheets for SI-2 hydrochloride
References for SI-2 hydrochloride
References are publications that support the biological activity of the product.
Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID: 27084884
If you know of a relevant reference for SI-2 hydrochloride, please let us know.
View Related Products by Target
Keywords: SI-2 hydrochloride, SI-2 hydrochloride supplier, steroid, receptor, coactivator-3, SRC3, inhibitors, inhibits, breast, cancers, orally, available, 223788-33-8, Other, Nuclear, Receptors, Histone, Acetyltransferases, Transcription, Factors, 5964, Tocris Bioscience
1 Citation for SI-2 hydrochloride
Citations are publications that use Tocris products. Selected citations for SI-2 hydrochloride include:
Wei et al (2021) SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning. J Biol Chem 297 101044 PMID: 34358562
Do you know of a great paper that uses SI-2 hydrochloride from Tocris? Please let us know.
Reviews for SI-2 hydrochloride
There are currently no reviews for this product. Be the first to review SI-2 hydrochloride and earn rewards!
Have you used SI-2 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.