SI-2 hydrochloride

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Description: Steroid receptor coactivator 3 (SRC-3) inhibitor
Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for SI-2 hydrochloride

SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Technical Data for SI-2 hydrochloride

M. Wt 301.78
Formula C15H15N5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 121513909
Smiles CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SI-2 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 15.09 50
DMSO 6.04 20

Preparing Stock Solutions for SI-2 hydrochloride

The following data is based on the product molecular weight 301.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.63 mL 33.14 mL 66.27 mL
2.5 mM 1.33 mL 6.63 mL 13.25 mL
5 mM 0.66 mL 3.31 mL 6.63 mL
25 mM 0.13 mL 0.66 mL 1.33 mL

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Product Datasheets for SI-2 hydrochloride

References for SI-2 hydrochloride

References are publications that support the biological activity of the product.

Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID: 27084884

If you know of a relevant reference for SI-2 hydrochloride, please let us know.

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1 Citation for SI-2 hydrochloride

Citations are publications that use Tocris products. Selected citations for SI-2 hydrochloride include:

Wei et al (2021) SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning. J Biol Chem 297 101044 PMID: 34358562

Do you know of a great paper that uses SI-2 hydrochloride from Tocris? Please let us know.

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