SI-2 hydrochloride

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Cat.No. 5964 - SI-2 hydrochloride | C15H15N5.HCl
Description: Steroid receptor coactivator 3 (SRC-3) inhibitor
Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Technical Data

M. Wt 301.78
Formula C15H15N5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 121513909
InChI Key CDYJHORKRVKALB-NWBUNABESA-N
Smiles CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.04 20
water 15.09 50

Preparing Stock Solutions

The following data is based on the product molecular weight 301.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.57 mL 33.14 mL
5 mM 0.66 mL 3.31 mL 6.63 mL
10 mM 0.33 mL 1.66 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Song et al (2016) Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 113 4970 PMID: 27084884


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Citations for SI-2 hydrochloride

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