SGS 518 oxalate

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Cat.No. 3688 - SGS 518 oxalate | C21H22F2N2O3S.C2H2O4 | CAS No. 445441-27-0
Description: Selective 5-HT6 antagonist
Alternative Names: LY 483518
Chemical Name: 1-Methyl-3-(1-methyl-4-piperindin-4-yl)-5-hydroxy-1H-indole 2,6-difluorobenzenesulfonic acid ester oxalate
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Selective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.

Technical Data

M. Wt 510.51
Formula C21H22F2N2O3S.C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 445441-27-0
PubChem ID 24880040
Smiles CN2C1=CC=C(OS(C4=C(F)C=CC=C4F)(=O)=O)C=C1C(C3CCN(C)CC3)=C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 510.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.79 mL 19.59 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References are publications that support the biological activity of the product.

Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197 PMID: 18044950

Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133 PMID: 16865095

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Literature in this Area

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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.


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