SGS 518 oxalate

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Cat.No. 3688 - SGS 518 oxalate | C21H22F2N2O3S.C2H2O4 | CAS No. 445441-27-0
Description: Selective 5-HT6 antagonist
Alternative Names: LY 483518
Chemical Name: 1-Methyl-3-(1-methyl-4-piperindin-4-yl)-5-hydroxy-1H-indole 2,6-difluorobenzenesulfonic acid ester oxalate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective antagonist of the 5-HT6 subtype of the serotonin receptor. Useful for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease.

Technical Data

M. Wt 510.51
Formula C21H22F2N2O3S.C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 445441-27-0
PubChem ID 24880040
InChI Key XQGFYENETWVJEU-UHFFFAOYSA-N
Smiles CN2C1=CC=C(OS(C4=C(F)C=CC=C4F)(=O)=O)C=C1C(C3CCN(C)CC3)=C2.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 510.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.79 mL 19.59 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2008) New serotonin 5-HT6 ligands from common feature pharmacophore hypotheses. J.Chem.Inf.Model. 48 197 PMID: 18044950

Romero et al (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. Br.J.Pharmocol. 148 1133 PMID: 16865095


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Keywords: SGS518 5-HTreceptors serotonin antagonists schizophrenia Alzheimers LY483518 LY 483518 5-HT6 Receptors

Citations for SGS 518 oxalate

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