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Description: Negative control for SGC AAK1 1 (Cat.No. 6528)
Chemical Name: N-[6-[3-[(Cyclopropylsulfonyl)amino]phenyl]-1H-indazol-3-yl]-2-methylpropanamide
Purity: ≥97% (HPLC)

Biological Activity for SGC AAK1 1N

SGC AAK1 1N is a negative control for SGC AAK1 1 (Cat. No. 6528).

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.

Technical Data for SGC AAK1 1N

M. Wt 398.48
Formula C20H22N4O3S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2242913-80-8
PubChem ID 146121078
Smiles O=C(C(C)C)NC1=NNC2=C1C=CC(C3=CC=CC(NS(=O)(C4CC4)=O)=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SGC AAK1 1N

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.85 100
ethanol 3.98 10

Preparing Stock Solutions for SGC AAK1 1N

The following data is based on the product molecular weight 398.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for SGC AAK1 1N

References are publications that support the biological activity of the product.

Agajanian (2019) WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of LRP6 and establish a negative feedback loop. Cell Rep. 26 79 PMID: 30605688

If you know of a relevant reference for SGC AAK1 1N, please let us know.

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Citations for SGC AAK1 1N

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