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SEA 0400

Cat. No. 6164 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 6164 - SEA 0400 | C21H19F2NO3 | CAS No. 223104-29-8
Description: Potent Na+/Ca2+ exchanger (NCX) inhibitor
Chemical Name: 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent Na+/Ca2+ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50 values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.

Compound Libraries

SEA 0400 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.38
Formula C21H19F2NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 223104-29-8
PubChem ID 644100
InChI Key YSUBLPUJDOWYDP-UHFFFAOYSA-N
Smiles CCOC1=CC(N)=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(F)=C3)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.14 100
ethanol 37.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 371.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Takahashi et al (2003) Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries. Eur.J.Pharmacol. 458 155 PMID: 12498920

Christ et al (2016) Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation. Eur.J.Pharmacol. 788 286 PMID: 27373849

Karashima et al (2007) Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice. Br.J.Pharmacol. 150 343 PMID: 17220909

If you know of a relevant reference for SEA 0400, please let us know.

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Keywords: SEA 0400, SEA 0400 supplier, SEA0400, Inhibitors, Inhibits, NCX, Na+/Ca2+, exchanger, cardioprotectant, Exchanger, 6164, Tocris Bioscience

1 Citation for SEA 0400

Citations are publications that use Tocris products. Selected citations for SEA 0400 include:

Neubert et al (2020) NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages. PLoS Biol 18 PMID: 32569301

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Literature in this Area

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Cardiovascular Research Product Guide

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