β-adrenoceptor and 5-HT1A/1B receptor antagonist. pKB/pA2 values are 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors respectively. Centrally active following systemic administration in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 348.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.87 mL||14.35 mL||28.7 mL|
|5 mM||0.57 mL||2.87 mL||5.74 mL|
|10 mM||0.29 mL||1.43 mL||2.87 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Chojnacka-Wojcik and Przegalinski (1991) Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats. Neuropharmacology 30 703 PMID: 1681448
Hoyer et al (1994) VII International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
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Keywords: β-adrenoceptor beta-adrenoceptor b-adrenoceptor antagonists 5-HT1A/1B β-adrenergic beta-adrenergic b-adrenergic Receptors Non-Selective Serotonin SDZ21009 Non-selective Adrenergic Beta Receptors
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