SDZ 21009

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Cat.No. 1516 - SDZ 21009 | C19H28N2O4 | CAS No. 39731-05-0
Description: β-adrenoceptor antagonist; also 5-HT1A and 5-HT1B antagonist
Chemical Name: 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylic acid, 1-methylethyl ester
Literature (4)

Biological Activity for SDZ 21009

SDZ 21009 is an β-adrenoceptor and 5-HT1A/1B receptor antagonist. pKB/pA2 values are 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors respectively. Centrally active following systemic administration in vivo.

Technical Data for SDZ 21009

M. Wt 348.44
Formula C19H28N2O4
Storage Store at RT
CAS Number 39731-05-0
PubChem ID 193949
Smiles CC(C)OC(=O)C1=CC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SDZ 21009

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 34.84 100
DMSO 34.84 100

Preparing Stock Solutions for SDZ 21009

The following data is based on the product molecular weight 348.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References for SDZ 21009

References are publications that support the biological activity of the product.

Chojnacka-Wojcik and Przegalinski (1991) Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats. Neuropharmacology 30 703 PMID: 1681448

Hoyer et al (1994) VII International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Engel et al (1986) Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmied.Arch.Pharmacol. 332 1

If you know of a relevant reference for SDZ 21009, please let us know.

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Keywords: SDZ 21009, SDZ 21009 supplier, β-adrenoceptor, beta-adrenoceptor, b-adrenoceptor, antagonists, 5-HT1A/1B, β-adrenergic, beta-adrenergic, b-adrenergic, Receptors, Non-Selective, Serotonin, SDZ21009, Non-selective, Adrenergic, Beta, 5-HT1A, 5-HT1B, 1516, Tocris Bioscience

Citations for SDZ 21009

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