SDZ 205-557 hydrochloride

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Cat.No. 2037 - SDZ 205-557 hydrochloride | C14H21ClN2O3.HCl | CAS No. 1197334-02-3
Description: 5-HT4/5-HT3 receptor antagonist
Chemical Name: 4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT3/5-HT4 receptor antagonist.

Technical Data

M. Wt 337.25
Formula C14H21ClN2O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1197334-02-3
PubChem ID 11957705
InChI Key JOWUQCJWCRNVMQ-UHFFFAOYSA-N
Smiles Cl.CCN(CC)CCOC(=O)C1=CC(Cl)=C(N)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 337.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.83 mL 29.65 mL
5 mM 0.59 mL 2.97 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Eglen et al (1993) The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors. Br.J.Pharmacol. 108 376 PMID: 8448587

McMahon and Cunningham (1999) Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J.Pharmacol.Exp.Ther. 291 300 PMID: 10490917

Buchheit et al (1992) SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. Naunyn-Schmied.Arch.Pharmacol. 345 387 PMID:


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Citations for SDZ 205-557 hydrochloride

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