Scriptaid

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Cat.No. 2421 - Scriptaid | C18H18N2O4 | CAS No. 287383-59-9
Description: Histone deacetylase inhibitor
Chemical Name: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (3)

Biological Activity

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Technical Data

M. Wt 326.35
Formula C18H18N2O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 287383-59-9
PubChem ID 5186
InChI Key JTDYUFSDZATMKU-UHFFFAOYSA-N
Smiles ONC(=O)CCCCCN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 326.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.32 mL 30.64 mL
5 mM 0.61 mL 3.06 mL 6.13 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References

References are publications that support the biological activity of the product.

Su et al (2000) A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 60 3137 PMID: 10866300


If you know of a relevant reference for Scriptaid, please let us know.

View Related Products by Product Action

View all Non-selective Histone Deacetylase Inhibitors

Keywords: Scriptaid, Scriptaid supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, Non-selective, HDACs, Non-Selective, 2421, Tocris Bioscience

2 Citations for Scriptaid

Citations are publications that use Tocris products. Selected citations for Scriptaid include:

Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J Cancer 118 1359 PMID: 29695769

Sharma et al (2010) HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. J Cell Mol Med 14 2151 PMID: 19583803


Do you know of a great paper that uses Scriptaid from Tocris? Please let us know.

Reviews for Scriptaid

Average Rating: 5 (Based on 1 Review.)

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TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot..
By Anonymous on 11/15/2019
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: C3-TAg tumour cell

TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot.

PMID: 29695769
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.