Scriptaid

Discontinued Product

Scriptaid (Cat. No. 2421) has been withdrawn from sale for commercial reasons.
Description: Histone deacetylase inhibitor
Chemical Name: N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (2)

Biological Activity for Scriptaid

Scriptaid is a novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Technical Data for Scriptaid

M. Wt 326.35
Formula C18H18N2O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 287383-59-9
PubChem ID 5186
InChI Key JTDYUFSDZATMKU-UHFFFAOYSA-N
Smiles ONC(=O)CCCCCN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Scriptaid

References are publications that support the biological activity of the product.

Su et al (2000) A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 60 3137 PMID: 10866300

View Related Products by Product Action

View all Non-selective Histone Deacetylase Inhibitors

Keywords: Scriptaid, Scriptaid supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, Non-selective, HDACs, Non-Selective, 2421, Tocris Bioscience

2 Citations for Scriptaid

Citations are publications that use Tocris products. Selected citations for Scriptaid include:

Sharma et al (2010) HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. J Cell Mol Med 14 2151 PMID: 19583803

Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J Cancer 118 1359 PMID: 29695769


Reviews for Scriptaid

Average Rating: 5 (Based on 1 Review.)

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TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot..
By Anonymous on 11/15/2019
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: C3-TAg tumour cell

TGF beta high responder treated with 2 μM Scriptaid (HDAC 1/3/8 inhibitor) for 48 h. Cell lysates were analysed by western blot.

PMID: 29695769
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.