You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for SCH 28080
SCH 28080 is a potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo.
Technical Data for SCH 28080
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SCH 28080
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SCH 28080
The following data is based on the product molecular weight 277.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||14.42 mL||72.12 mL||144.23 mL|
|1.25 mM||2.88 mL||14.42 mL||28.85 mL|
|2.5 mM||1.44 mL||7.21 mL||14.42 mL|
|12.5 mM||0.29 mL||1.44 mL||2.88 mL|
References for SCH 28080
References are publications that support the biological activity of the product.
Long et al (1983) Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 226 114 PMID: 6864535
Scott et al (1987) Studies on the mechanism of action of the gastric microsomal (H+K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 36 97 PMID: 3026407
Vagin et al (2002) SCH 28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain. Biochemistry 41 12755 PMID: 12379118
If you know of a relevant reference for SCH 28080, please let us know.
View Related Products by Product Action
Keywords: SCH 28080, SCH 28080 supplier, H+K+-ATPase, inhibitors, inhibits, P-Type, ATPase, Ion, Transporters, Pumps, hydrogen, potassium-ATPase, SCH28080, H+,K+-ATPase, 1690, Tocris Bioscience
1 Citation for SCH 28080
Citations are publications that use Tocris products. Selected citations for SCH 28080 include:
Lynch et al (2010) Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct. Am J Physiol Renal Physiol 298 F408 PMID: 19923411
Do you know of a great paper that uses SCH 28080 from Tocris? Please let us know.
Reviews for SCH 28080
There are currently no reviews for this product. Be the first to review SCH 28080 and earn rewards!
Have you used SCH 28080?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image