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Cat.No. 0433 - SC-9 | C22H24ClNO2S | CAS No. 102649-78-5
Description: Protein kinase C activator
Chemical Name: 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide
Purity: ≥99% (HPLC)
Reviews (1)
Literature (3)

Biological Activity for SC-9

SC-9 is a potent activator of protein kinase C.

Technical Data for SC-9

M. Wt 401.95
Formula C22H24ClNO2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 102649-78-5
PubChem ID 124172
Smiles ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)NCCCCCCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SC-9

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 10.05 25
DMSO 40.2 100

Preparing Stock Solutions for SC-9

The following data is based on the product molecular weight 401.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.88 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for SC-9

Certificate of Analysis / Product Datasheet
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References for SC-9

References are publications that support the biological activity of the product.

Ito et al (1986) N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C. Biochemistry 25 4179 PMID: 3756133

Nishino et al (1986) N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+ -activated, phospholipid-dependent protein kinase. Biochim.Biophys.Acta. 889 236 PMID: 3778949

If you know of a relevant reference for SC-9, please let us know.

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Keywords: SC-9, SC-9 supplier, Protein, kinase, C, activators, PKC, PKM, Kinases, Kinase, Enzyme, Substrates, /, Activators, 0433, Tocris Bioscience

Citations for SC-9

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Currently there are no citations for SC-9. Do you know of a great paper that uses SC-9 from Tocris? Please let us know.

Reviews for SC-9

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Clot lysis activity screening of crude enzymes assessed.
By Anonymous on 11/13/2018
Assay Type: In Vitro
Species: Human

The clot lysis activity screening of the crude enzymes (100µl each) was done as triplet on 0.5 ml human blood with SC-9 kinase (30,000 IU/ml) as positive control and distilled water as negative thrombolytic control. All the crude enzymes of mutated Isolates showed good clot lysis activity.

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Literature in this Area

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