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Description: Protein kinase C activator
Chemical Name: 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide
Purity: ≥99% (HPLC)
Biological Activity
A potent activator of protein kinase C.
Compound Libraries
SC-9 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 401.95 |
| Formula | C22H24ClNO2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 102649-78-5 |
| PubChem ID | 124172 |
| InChI Key | YUXMTDYHFPRPLG-UHFFFAOYSA-N |
| Smiles | ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)NCCCCCCC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 10.05 | 25 | |
| DMSO | 40.2 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 401.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.44 mL | 24.88 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Ito et al (1986) N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C. Biochemistry 25 4179 PMID: 3756133
Nishino et al (1986) N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+ -activated, phospholipid-dependent protein kinase. Biochim.Biophys.Acta. 889 236 PMID: 3778949
If you know of a relevant reference for SC-9, please let us know.
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Keywords: SC-9, SC-9 supplier, Protein, kinase, C, activators, PKC, PKM, Kinases, Kinase, Enzyme, Substrates, /, Activators, 0433, Tocris Bioscience
Citations for SC-9
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Reviews for SC-9
Average Rating: 5 (Based on 1 Review.)
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Clot lysis activity screening of crude enzymes assessed: Excellent publishable, performed ideally.
By
Anonymous on 11/13/2018
Assay Type: In Vitro
Species: Human
The clot lysis activity screening of the crude enzymes (100µl each) was done as triplet on 0.5 ml human blood with SC-9 kinase (30,000 IU/ml) as positive control and distilled water as negative thrombolytic control. All the crude enzymes of mutated Isolates showed good clot lysis activity.
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