SB 268262

Discontinued Product

SB 268262 (Cat. No. 4314) has been withdrawn from sale for commercial reasons.
Description: Selective non-peptide CGRP antagonist
Chemical Name: N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity for SB 268262

SB 268262 is a selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline.

Technical Data for SB 268262

M. Wt 401.46
Formula C18H15N3O4S2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 217438-17-0
PubChem ID 6918567
InChI Key YXHLPJQQPOMPGE-UHFFFAOYSA-N
Smiles O=S(C2=NC=CS2)C1=CC=C(C(N(C)C3=CC=CC=C3C)=O)C=C1[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SB 268262

References are publications that support the biological activity of the product.

Aiyar et al (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 296 768 PMID: 11181905

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Keywords: SB 268262, SB 268262 supplier, SB268262, CGRP, receptor, antagonist, calcitonin, gene-related, peptide, 1, antagonists, CGRP1, Calcitonin, and, Related, Receptors, 4314, Tocris Bioscience

1 Citation for SB 268262

Citations are publications that use Tocris products. Selected citations for SB 268262 include:

Matthias et al (2021) Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes. Front Immunol 12 722884 PMID: 34512650


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.