SB 268262

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Cat.No. 4314 - SB 268262 | C18H15N3O4S2 | CAS No. 217438-17-0
Description: Selective non-peptide CGRP antagonist
Chemical Name: N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for SB 268262

SB 268262 is a selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline.

Technical Data for SB 268262

M. Wt 401.46
Formula C18H15N3O4S2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 217438-17-0
PubChem ID 6918567
InChI Key YXHLPJQQPOMPGE-UHFFFAOYSA-N
Smiles O=S(C2=NC=CS2)C1=CC=C(C(N(C)C3=CC=CC=C3C)=O)C=C1[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SB 268262

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.07 50

Preparing Stock Solutions for SB 268262

The following data is based on the product molecular weight 401.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.98 mL 24.91 mL 49.82 mL
2.5 mM 1 mL 4.98 mL 9.96 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
25 mM 0.1 mL 0.5 mL 1 mL

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References for SB 268262

References are publications that support the biological activity of the product.

Aiyar et al (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 296 768 PMID: 11181905


If you know of a relevant reference for SB 268262, please let us know.

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Keywords: SB 268262, SB 268262 supplier, SB268262, CGRP, receptor, antagonist, calcitonin, gene-related, peptide, 1, antagonists, CGRP1, Calcitonin, and, Related, Receptors, 4314, Tocris Bioscience

Citations for SB 268262

Citations are publications that use Tocris products.

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Reviews for SB 268262

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Literature in this Area

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