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Submit ReviewSB 268262
Description: Selective non-peptide CGRP antagonist
Chemical Name: N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
Purity: ≥99% (HPLC)
Biological Activity for SB 268262
SB 268262 is a selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).
Licensing Information
Sold with the permission of GlaxoSmithKline.
Technical Data for SB 268262
| M. Wt | 401.46 |
| Formula | C18H15N3O4S2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 217438-17-0 |
| PubChem ID | 6918567 |
| InChI Key | YXHLPJQQPOMPGE-UHFFFAOYSA-N |
| Smiles | O=S(C2=NC=CS2)C1=CC=C(C(N(C)C3=CC=CC=C3C)=O)C=C1[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SB 268262
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.07 | 50 |
Preparing Stock Solutions for SB 268262
The following data is based on the product molecular weight 401.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.98 mL | 24.91 mL | 49.82 mL |
| 2.5 mM | 1 mL | 4.98 mL | 9.96 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
| 25 mM | 0.1 mL | 0.5 mL | 1 mL |
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Product Datasheets for SB 268262
References for SB 268262
References are publications that support the biological activity of the product.
Aiyar et al (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 296 768 PMID: 11181905
If you know of a relevant reference for SB 268262, please let us know.
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Keywords: SB 268262, SB 268262 supplier, SB268262, CGRP, receptor, antagonist, calcitonin, gene-related, peptide, 1, antagonists, CGRP1, Calcitonin, and, Related, Receptors, 4314, Tocris Bioscience
Citations for SB 268262
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