SB 243213 dihydrochloride

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Cat.No. 3527 - SB 243213 dihydrochloride | C22H19F3N4O2.2HCl | CAS No. 1780372-25-9
Description: Selective 5-HT2C inverse agonist
Chemical Name: 2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (4)

Biological Activity for SB 243213 dihydrochloride

SB 243213 dihydrochloride is a selective 5-HT2C inverse agonist (pKb = 9.8). Displays selectivity over other 5-HT2 subtypes (pKi values are 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C respectively); also exhibits >100-fold selectivity over 50 other receptors, ion channels and enzymes. Displays anxiolytic activity in rat models.

Technical Data for SB 243213 dihydrochloride

M. Wt 501.33
Formula C22H19F3N4O2.2HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1780372-25-9
PubChem ID 90488853
Smiles O=C(N3C(C=C(C(F)(F)F)C(C)=C4)=C4CC3)NC(C=C2)=CN=C2OC1=CC=CN=C1C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SB 243213 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.07 50

Preparing Stock Solutions for SB 243213 dihydrochloride

The following data is based on the product molecular weight 501.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.99 mL 19.95 mL 39.89 mL
2.5 mM 0.8 mL 3.99 mL 7.98 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
25 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets for SB 243213 dihydrochloride

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1 Citation for SB 243213 dihydrochloride

Citations are publications that use Tocris products. Selected citations for SB 243213 dihydrochloride include:

Ward et al (2015) Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. Nat Commun 290 12844 PMID: 25825490

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Literature in this Area

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