SB 203186 hydrochloride

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Cat.No. 0785 - SB 203186 hydrochloride | C16H20N2O2.HCl | CAS No. 207572-69-8
Description: 5-HT4 antagonist
Chemical Name: 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity for SB 203186 hydrochloride

SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for SB 203186 hydrochloride

M. Wt 308.81
Formula C16H20N2O2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 207572-69-8
PubChem ID 9926639

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SB 203186 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for SB 203186 hydrochloride

The following data is based on the product molecular weight 308.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.19 mL 32.38 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets for SB 203186 hydrochloride

Certificate of Analysis / Product Datasheet
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References for SB 203186 hydrochloride

References are publications that support the biological activity of the product.

McLean and Coupar (1995) 5-HT4 receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch.Pharmacol. 352 132 PMID: 747435

Midhurst and Kaumann et al (1993) Characterisation of 5-HT4 receptor mediating tachycardia in piglet isolated right atrium. Br.J.Pharmacol. 110 1023 PMID: 8298790

Parker et al (1995) Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn Schmiedebergs Arch.Pharmacol. 353 28 PMID: 8750913

If you know of a relevant reference for SB 203186 hydrochloride, please let us know.

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Citations for SB 203186 hydrochloride

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