SB 203186 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0785 - SB 203186 hydrochloride | C16H20N2O2.HCl | CAS No. 207572-69-8
Description: 5-HT4 antagonist
Chemical Name: 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 308.81
Formula C16H20N2O2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 07572-69-8
PubChem ID 9926639
InChI Key LYMBEMCUJNDSBZ-UHFFFAOYSA-N
Smiles Cl.O=C(OCCN1CCCCC1)C1=CNC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 308.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.19 mL 32.38 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

McLean and Coupar (1995) 5-HT4 receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch.Pharmacol. 352 132 PMID: 747435

Midhurst and Kaumann et al (1993) Characterisation of 5-HT4 receptor mediating tachycardia in piglet isolated right atrium. Br.J.Pharmacol. 110 1023 PMID: 8298790

Parker et al (1995) Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn Schmiedebergs Arch.Pharmacol. 353 28 PMID: 8750913


If you know of a relevant reference for SB 203186 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT4 Receptor Antagonists

Keywords: 5-HT4 antagonists Serotonin Receptors 5-Hydroxytryptamine 5-HT SB203186 hydrochloride GlaxoSmithKline GSK 5-HT4 Receptors

Citations for SB 203186 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for SB 203186 hydrochloride. Do you know of a great paper that uses SB 203186 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for SB 203186 hydrochloride

Protocols

TODO: Add Protocols