SAR 216471 hydrochloride

Discontinued Product

SAR 216471 hydrochloride (Cat. No. 5650) has been withdrawn from sale for commercial reasons.
Cat.No. 5650 - SAR 216471 hydrochloride | C28H31ClN8O3.HCl | CAS No. 1279829-64-9
Description: Potent P2Y12 antagonist; orally available
Chemical Name: 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity for SAR 216471 hydrochloride

SAR 216471 hydrochloride is a potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.

Technical Data for SAR 216471 hydrochloride

M. Wt 599.51
Formula C28H31ClN8O3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1279829-64-9
PubChem ID 70926954
InChI Key UQLWHBMSQKUYAI-UHFFFAOYSA-N
Smiles ClC1=CC=C2C(C(C(NC3=CC=C(N4C(C)=C(C(CCC)=O)C=N4)N=N3)=O)=CN2CC(N5CCN(C)CC5)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SAR 216471 hydrochloride

References for SAR 216471 hydrochloride

References are publications that support the biological activity of the product.

Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID: 25075638

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1 Citation for SAR 216471 hydrochloride

Citations are publications that use Tocris products. Selected citations for SAR 216471 hydrochloride include:

Liu et al (2018) Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Sci Rep 8 11380 PMID: 30038283


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

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Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.