SAR 216471 hydrochloride

Pricing Availability   Qty
Cat.No. 5650 - SAR 216471 hydrochloride | C28H31ClN8O3.HCl | CAS No. 1279829-64-9
Description: Potent P2Y12 antagonist; orally available
Chemical Name: 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.

Technical Data

M. Wt 599.51
Formula C28H31ClN8O3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1279829-64-9
PubChem ID 70926954
InChI Key UQLWHBMSQKUYAI-UHFFFAOYSA-N
Smiles ClC1=CC=C2C(C(C(NC3=CC=C(N4C(C)=C(C(CCC)=O)C=N4)N=N3)=O)=CN2CC(N5CCN(C)CC5)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.99 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 599.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.34 mL 41.7 mL 83.4 mL
1 mM 1.67 mL 8.34 mL 16.68 mL
2 mM 0.83 mL 4.17 mL 8.34 mL
10 mM 0.17 mL 0.83 mL 1.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID: 25075638


If you know of a relevant reference for SAR 216471 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Purinergic (P2Y) Receptor Antagonists

Keywords: SAR 216471 hydrochloride, SAR 216471 hydrochloride supplier, SAR216471, hydrochloride, potent, P2Y12, antagonists, antiplatelets, antithrombotics, orally, available, bioavailable, purine, receptors, purinoceptors, purinergic, Purinergic, P2Y, Receptors, 5650, Tocris Bioscience

Citations for SAR 216471 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for SAR 216471 hydrochloride. Do you know of a great paper that uses SAR 216471 hydrochloride from Tocris? Please let us know.

Reviews for SAR 216471 hydrochloride

There are currently no reviews for this product. Be the first to review SAR 216471 hydrochloride and earn rewards!

Have you used SAR 216471 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.