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SAR 216471 hydrochloride
Potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||11.99||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 599.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.34 mL||41.7 mL||83.4 mL|
|1 mM||1.67 mL||8.34 mL||16.68 mL|
|2 mM||0.83 mL||4.17 mL||8.34 mL|
|10 mM||0.17 mL||0.83 mL||1.67 mL|
References are publications that support the biological activity of the product.
Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID: 25075638
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1 Citation for SAR 216471 hydrochloride
Citations are publications that use Tocris products. Selected citations for SAR 216471 hydrochloride include:
Liu et al (2018) Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Sci Rep 8 11380 PMID: 30038283
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Literature in this Area
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