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Submit ReviewSAR 216471 hydrochloride
Discontinued Product
SAR 216471 hydrochloride (Cat. No. 5650) has been withdrawn from sale for commercial reasons.
Description: Potent P2Y12 antagonist; orally available
Chemical Name: 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SAR 216471 hydrochloride
SAR 216471 hydrochloride is a potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.
Technical Data for SAR 216471 hydrochloride
| M. Wt | 599.51 |
| Formula | C28H31ClN8O3.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1279829-64-9 |
| PubChem ID | 70926954 |
| InChI Key | UQLWHBMSQKUYAI-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2C(C(C(NC3=CC=C(N4C(C)=C(C(CCC)=O)C=N4)N=N3)=O)=CN2CC(N5CCN(C)CC5)=O)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SAR 216471 hydrochloride
References for SAR 216471 hydrochloride
References are publications that support the biological activity of the product.
Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID: 25075638
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Keywords: SAR 216471 hydrochloride, SAR 216471 hydrochloride supplier, SAR216471, hydrochloride, potent, P2Y12, antagonists, antiplatelets, antithrombotics, orally, available, bioavailable, purine, receptors, purinoceptors, purinergic, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 5650, Tocris Bioscience
1 Citation for SAR 216471 hydrochloride
Citations are publications that use Tocris products. Selected citations for SAR 216471 hydrochloride include:
Liu et al (2018) Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Sci Rep 8 11380 PMID: 30038283
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