Saquinavir mesylate

Pricing Availability   Qty
Description: HIV protease inhibitor
Alternative Names: Ro 31-8959
Chemical Name: (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for Saquinavir mesylate

Saquinavir mesylate is an inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.

Compound Libraries for Saquinavir mesylate

Saquinavir mesylate is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Saquinavir mesylate

M. Wt 766.95
Formula C38H50N6O5.CH4O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 149845-06-7
PubChem ID 60934
Smiles O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)[C@H](O)CN3C[C@](CCCC5)([H])[C@]5([H])C[C@H]3[C@@](NC(C)(C)C)=O)=O)C2=NC1=CC=CC=C1C=C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Saquinavir mesylate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.35 50

Preparing Stock Solutions for Saquinavir mesylate

The following data is based on the product molecular weight 766.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.61 mL 13.04 mL 26.08 mL
2.5 mM 0.52 mL 2.61 mL 5.22 mL
5 mM 0.26 mL 1.3 mL 2.61 mL
25 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for Saquinavir mesylate

References for Saquinavir mesylate

References are publications that support the biological activity of the product.

Krausslich et al (1992) Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation. J.Virol. 66 567 PMID: 1727499

Tucker et al (1992) A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. J.Med.Chem. 35 2525 PMID: 1635054

Kaldor et al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5 721

Roberts et al (1990) Rational design of peptide-based HIV proteinase inhibitors. Science 248 358 PMID: 2183354

If you know of a relevant reference for Saquinavir mesylate, please let us know.

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1 Citation for Saquinavir mesylate

Citations are publications that use Tocris products. Selected citations for Saquinavir mesylate include:

Lan et al (2014) Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells. J Immunol 193 3577 PMID: 25149467

Do you know of a great paper that uses Saquinavir mesylate from Tocris? Please let us know.

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