SAMS Peptide

Pricing Availability Delivery Time Qty
Cat.No. 1344 - SAMS Peptide | His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg | CAS No. 125911-68-4
Description: AMP-activated protein kinase substrate
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Substrate for AMP-activated protein kinase (AMPK). Phosphorylated rapidly by AMPK, it is more specific for the kinase than acetyl CoA carboxylase itself, and provides a convenient and sensitive assay for AMPK.

Technical Data

M. Wt 1779.15
Formula C74H131N29O18S2
Sequence HMRSAMSGLHLVKRR
Storage Desiccate at -20°C
CAS Number 125911-68-4
PubChem ID 71773161
InChI Key YJAHUEAICBOBTC-CSVPVIMBSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1779.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.56 mL 2.81 mL 5.62 mL
5 mM 0.11 mL 0.56 mL 1.12 mL
10 mM 0.06 mL 0.28 mL 0.56 mL
50 mM 0.01 mL 0.06 mL 0.11 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Carling et al (1989) Purification and characterization of the AMP-activated protein kinase. Eur.J.Biochem. 186 129 PMID: 2598924

Davies et al (1989) Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur.J.Biochem. 186 123 PMID: 2574667

Hardie et al (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu.Rev.Biochem 67 821 PMID: 9759505


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Keywords: SAMS Peptide, supplier, AMP-activated, protein, kinase, AMPK, Kinases, Enzyme, Substrates, Activators, Enzyme, Substrates, /, Activators, AMPK, AMPK, Tocris Bioscience

1 Citation for SAMS Peptide

Citations are publications that use Tocris products. Selected citations for SAMS Peptide include:

Thelander et al (2004) Snf1-related protein kinase 1 is needed for growth in a normal day-night light cycle. EMBO J 23 1900 PMID: 15057278


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Literature in this Area

Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for SAMS Peptide

AMPK

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.