Salmeterol

Description: Potent β2 agonist; long acting
Alternative Names: GR 33343
Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM); bronchodilator. Unlike other β2 agonists, binds to exo-site domain of β2 receptors, producing a slow onset of action and prolonged activation. Also available as part of the β-Adrenoceptor Agonist Tocriset™.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 415.57
Formula C25H37NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 89365-50-4
Smiles Oc1ccc(C(CNCCCCCCOCCCCc2ccccc2)O)cc1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 415.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.03 mL 24.06 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Clark et al (1996) Stable activation and desensitization of β2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite. Mol.Pharmacol. 49 182 PMID: 8569705

Ellis et al (1995) Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle. Br.J.Pharmacol. 116 2510 PMID: 8581292

Johnson et al (1993) The pharmacology of salmeterol. Life Sci. 52 2131 PMID: 8099695

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Keywords: Potent α2-adrenoceptor beta2-adrenoceptor b2-adrenoceptor agonists long acting β2-adrenergic α2-adrenergic beta2-adrenergic b2-adrenergic Receptors GR33343 GlaxoSmithKline GSK GR 33343 Adrenergic Beta-2 Receptors

Citations for Salmeterol

Citations are publications that use Tocris products.

Currently there are no citations for Salmeterol.

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Pathways for Salmeterol

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