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Potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM); bronchodilator. Unlike other β2 agonists, binds to exo-site domain of β2 receptors, producing a slow onset of action and prolonged activation.
Sold for research purposes under agreement from GlaxoSmithKline
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Clark et al (1996) Stable activation and desensitization of β2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite. Mol.Pharmacol. 49 182 PMID: 8569705
Ellis et al (1995) Correlation of cyclic AMP accumulation and relaxant actions of salme. and salbutamol in bovine tracheal smooth muscle. Br.J.Pharmacol. 116 2510 PMID: 8581292
Johnson et al (1993) The pharmacology of salme. Life Sci. 52 2131 PMID: 8099695
Keywords: Salmeterol, Salmeterol supplier, Potent, α2-adrenoceptor, beta2-adrenoceptor, b2-adrenoceptor, agonists, long, acting, β2-adrenergic, α2-adrenergic, beta2-adrenergic, b2-adrenergic, Receptors, GR33343, GlaxoSmithKline, GSK, GR, 33343, Adrenergic, Beta-2, 1660, Tocris Bioscience
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.