Potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM); bronchodilator. Unlike other β2 agonists, binds to exo-site domain of β2 receptors, producing a slow onset of action and prolonged activation. Also available as part of the β-Adrenoceptor Agonist Tocriset™.
Sold for research purposes under agreement from GlaxoSmithKline
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 415.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.03 mL||24.06 mL|
|5 mM||0.48 mL||2.41 mL||4.81 mL|
|10 mM||0.24 mL||1.2 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Clark et al (1996) Stable activation and desensitization of β2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite. Mol.Pharmacol. 49 182 PMID: 8569705
Ellis et al (1995) Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle. Br.J.Pharmacol. 116 2510 PMID: 8581292
Johnson et al (1993) The pharmacology of salmeterol. Life Sci. 52 2131 PMID: 8099695
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Keywords: Salmeterol, supplier, Potent, α2-adrenoceptor, beta2-adrenoceptor, b2-adrenoceptor, agonists, long, acting, β2-adrenergic, α2-adrenergic, beta2-adrenergic, b2-adrenergic, Receptors, GR33343, GlaxoSmithKline, GSK, GR, 33343, Adrenergic, Beta-2, Receptors, Adrenergic, Beta-2, Receptors, Tocris Bioscience
Citations for Salmeterol
Citations are publications that use Tocris products.
Currently there are no citations for Salmeterol.
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