Salmeterol

Description: Potent β2 agonist; long acting
Alternative Names: GR 33343
Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM); bronchodilator. Unlike other β2 agonists, binds to exo-site domain of β2 receptors, producing a slow onset of action and prolonged activation. Also available as part of the β-Adrenoceptor Agonist Tocriset™.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 415.57
Formula C25H37NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 89365-50-4
Smiles Oc1ccc(C(CNCCCCCCOCCCCc2ccccc2)O)cc1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Clark et al (1996) Stable activation and desensitization of β2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite. Mol.Pharmacol. 49 182 PMID: 8569705

Ellis et al (1995) Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle. Br.J.Pharmacol. 116 2510 PMID: 8581292

Johnson et al (1993) The pharmacology of salmeterol. Life Sci. 52 2131 PMID: 8099695

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Citations for Salmeterol

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Currently there are no citations for Salmeterol.

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