Salinomycin sodium salt

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Cat.No. 3637 - Salinomycin sodium salt | C42H69NaO11 | CAS No. 55721-31-8
Description: Antibiotic; also selectively inhibits cancer stem cells
Chemical Name: (2R)-2-[(2R,5S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid soldium salt
Literature (1)

Biological Activity

Cytotoxic to breast cancer stem cells. Inhibits CD44 expression in breast cancer cells in vitro. Inhibits mammary tumor growth in mice. Also antibiotic.

Technical Data

M. Wt 772.98
Formula C42H69NaO11
Storage Store at +4°C
CAS Number 55721-31-8
PubChem ID 45479870GC
Smiles C[C@@H]1[C@@]([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)[C@]2([H])[C@@H](C)C[C@@H](C)[C@]3(O[C@@]4(CC[C@]([C@@]5([H])CC[C@@](CC)(O)[C@H](C)O5)(C)O4)[C@H](O)C=C3)O2)=O)([H])O[C@]([C@@H](CC)C([O-])=O)([H])CC1.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.65 50
ethanol 77.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 772.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.29 mL 6.47 mL 12.94 mL
5 mM 0.26 mL 1.29 mL 2.59 mL
10 mM 0.13 mL 0.65 mL 1.29 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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References are publications that support the biological activity of the product.

Gupta et al (2009) Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 645 PMID: 19682730

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New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

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