Salinomycin sodium salt

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Cat.No. 3637 - Salinomycin sodium salt | C42H69NaO11 | CAS No. 55721-31-8
Description: Antibiotic; also selectively inhibits cancer stem cells
Chemical Name: (2R)-2-[(2R,5S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid soldium salt
Datasheet
Citations
Reviews
Literature

Biological Activity

Cytotoxic to breast cancer stem cells. Inhibits CD44 expression in breast cancer cells in vitro. Inhibits mammary tumor growth in mice. Also antibiotic.

Technical Data

M. Wt 772.98
Formula C42H69NaO11
Storage Store at +4°C
CAS Number 55721-31-8
PubChem ID 45479870GC
InChI Key GCVPRXBFNOZQIX-MMUBVBEESA-M
Smiles C[C@@H]1[C@@]([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)[C@]2([H])[C@@H](C)C[C@@H](C)[C@]3(O[C@@]4(CC[C@]([C@@]5([H])CC[C@@](CC)(O)[C@H](C)O5)(C)O4)[C@H](O)C=C3)O2)=O)([H])O[C@]([C@@H](CC)C([O-])=O)([H])CC1.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 77.3 100
DMSO 38.65 50

Preparing Stock Solutions

The following data is based on the product molecular weight 772.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.29 mL 6.47 mL 12.94 mL
5 mM 0.26 mL 1.29 mL 2.59 mL
10 mM 0.13 mL 0.65 mL 1.29 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Gupta et al (2009) Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 645 PMID: 19682730


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New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

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