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Potent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 <10 nM). Also inhibits MAGL at higher concentrations (IC50 values are 410 nM and 1.4 μM respectively). Inhibits both human and mouse FAAH enzymes. Exhibits inhibitory activity against FAAH, MAGL and ABHD6 in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 338.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||11.81 mL||59.03 mL||118.05 mL|
|1.25 mM||2.36 mL||11.81 mL||23.61 mL|
|2.5 mM||1.18 mL||5.9 mL||11.81 mL|
|12.5 mM||0.24 mL||1.18 mL||2.36 mL|
References are publications that support the biological activity of the product.
Niphakis et al (2012) O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem.Neurosci. 3 418 PMID: 22860211
Owens et al (2016) Discriminative stimulus properties of the endocannabinoid catabolic enzyme inhibitor SA-57 in mice. J.Pharmacol.Exp.Ther 358 306 PMID: 27307500
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Keywords: SA 57, SA 57 supplier, SA57, FAAH, fatty, acid, amide, hydrolase, inhibitors, inhibits, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4752, Tocris Bioscience
Citations for SA 57
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.