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Description: Potent FAAH inhibitor
Chemical Name: 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester
Purity: ≥99% (HPLC)
Biological Activity
Potent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 <10 nM). Also inhibits MAGL at higher concentrations (IC50 values are 410 nM and 1.4 μM respectively). Inhibits both human and mouse FAAH enzymes. Exhibits inhibitory activity against FAAH, MAGL and ABHD6 in vivo.
Technical Data
| M. Wt | 338.83 |
| Formula | C17H23ClN2O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1346169-63-8 |
| PubChem ID | 44589122 |
| InChI Key | JFSSVCSHPDLFCM-UHFFFAOYSA-N |
| Smiles | ClC(C=C2)=CC=C2CCC1CCN(C(OCC(NC)=O)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.47 | 25 | |
| ethanol | 6.78 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 338.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 11.81 mL | 59.03 mL | 118.05 mL |
| 1.25 mM | 2.36 mL | 11.81 mL | 23.61 mL |
| 2.5 mM | 1.18 mL | 5.9 mL | 11.81 mL |
| 12.5 mM | 0.24 mL | 1.18 mL | 2.36 mL |
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References
References are publications that support the biological activity of the product.
Niphakis et al (2012) O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem.Neurosci. 3 418 PMID: 22860211
Owens et al (2016) Discriminative stimulus properties of the endocannabinoid catabolic enzyme inhibitor SA-57 in mice. J.Pharmacol.Exp.Ther 358 306 PMID: 27307500
If you know of a relevant reference for SA 57, please let us know.
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Keywords: SA 57, SA 57 supplier, SA57, FAAH, fatty, acid, amide, hydrolase, inhibitors, inhibits, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4752, Tocris Bioscience
Citations for SA 57
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