SA 57

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Cat.No. 4752 - SA 57 | C17H23ClN2O3 | CAS No. 1346169-63-8
Description: Potent FAAH inhibitor
Chemical Name: 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 <10 nM). Also inhibits MAGL at higher concentrations (IC50 values are 410 nM and 1.4 μM respectively). Inhibits both human and mouse FAAH enzymes. Exhibits inhibitory activity against FAAH, MAGL and ABHD6 in vivo.

Technical Data

M. Wt 338.83
Formula C17H23ClN2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1346169-63-8
PubChem ID 44589122
InChI Key JFSSVCSHPDLFCM-UHFFFAOYSA-N
Smiles ClC(C=C2)=CC=C2CCC1CCN(C(OCC(NC)=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.78 20
DMSO 8.47 25

Preparing Stock Solutions

The following data is based on the product molecular weight 338.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.81 mL 59.03 mL 118.05 mL
1.25 mM 2.36 mL 11.81 mL 23.61 mL
2.5 mM 1.18 mL 5.9 mL 11.81 mL
12.5 mM 0.24 mL 1.18 mL 2.36 mL

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References

References are publications that support the biological activity of the product.

Niphakis et al (2012) O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem.Neurosci. 3 418 PMID: 22860211

Owens et al (2016) Discriminative stimulus properties of the endocannabinoid catabolic enzyme inhibitor SA-57 in mice. J.Pharmacol.Exp.Ther 358 306 PMID: 27307500


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Citations for SA 57

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