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Description: Selective FAAH inhibitor
Chemical Name: N-[2-[1-(6-Methyl-2-pyridinyl)-4-piperidinyl]ethyl]carbamic acid 2-(methylamino)-2-oxoethyl ester
Purity: ≥99% (HPLC)
Biological Activity for SA 47
SA 47 is a selective inhibitor of fatty acid amide hydrolase (FAAH). Exhibits greater selectivity for FAAH than URB 597 against multiple carboxylesterases.
Technical Data for SA 47
| M. Wt | 334.41 |
| Formula | C17H26N4O3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 792236-07-8 |
| PubChem ID | 9840648 |
| InChI Key | HSYCMGWPPRTNKH-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC(N2CCC(CCNC(OCC(NC)=O)=O)CC2)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SA 47
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.44 | 100 | |
| 1eq. HCl | 16.72 | 50 |
Preparing Stock Solutions for SA 47
The following data is based on the product molecular weight 334.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.99 mL | 14.95 mL | 29.9 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.98 mL |
| 10 mM | 0.3 mL | 1.5 mL | 2.99 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for SA 47
References for SA 47
References are publications that support the biological activity of the product.
Zhang et al (2007) Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology 52 1095 PMID: 17217969
Ahn et al (2009) Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin.Drug Discov. 4 763 PMID: 20544003
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Citations for SA 47
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