(S)-PFI 2 hydrochloride

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Cat.No. 5400 - (S)-PFI 2 hydrochloride | C23H25F4N3O3S.HCl | CAS No. 1627607-88-8
Description: Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
Chemical Name: (1S)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892). Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary on the SGC website.

Technical Data

M. Wt 535.98
Formula C23H25F4N3O3S.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1627607-88-8
PubChem ID 91691132
InChI Key ZADKZNVAJGEFLC-BOXHHOBZSA-N
Smiles O=C(N4CCCC4)[C@H](CC3=CC=CC(C(F)(F)F)=C3)NS(C2=CC1=C(C(F)=C2)CNCC1)(=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.6 100
ethanol 10.72 20

Preparing Stock Solutions

The following data is based on the product molecular weight 535.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.66 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Barsyte-Lovejoy et al (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.U S A 111 12853 PMID: 25136132


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Citations for (S)-PFI 2 hydrochloride

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Literature in this Area

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