(S)-Methylisothiourea sulfate

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Cat.No. 0776 - (S)-Methylisothiourea sulfate | C4H14N4O4S3 | CAS No. 867-44-7
Description: Highly selective iNOS inhibitor
Alternative Names: SMT
Datasheet
Citations (2)
Reviews
Literature (3)

Biological Activity

Highly selective, potent competitive inhibitor of iNOS.

Technical Data

M. Wt 278.36
Formula C4H14N4O4S3
Storage Store at RT
CAS Number 867-44-7
PubChem ID 13347
InChI Key BZZXQZOBAUXLHZ-UHFFFAOYSA-N
Smiles NC(SC)=[NH2+].NC(SC)=[NH2+].[O-]S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water

References

References are publications that support the biological activity of the product.

Iuvone et al (1997) Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat. Br.J.Pharmacol. 121 1637 PMID: 9283697

Southan et al (1995) Isothioureas - potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br.J.Pharmacol. 114 510 PMID: 7533622


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Keywords: (S)-Methylisothiourea sulfate, (S)-Methylisothiourea sulfate supplier, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, SMT, 0776, Tocris Bioscience

2 Citations for (S)-Methylisothiourea sulfate

Citations are publications that use Tocris products. Selected citations for (S)-Methylisothiourea sulfate include:

Chang et al (2002) Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat. Br J Pharmacol 136 43313 PMID: 11976262

Chan et al (2007) Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia. Mol Pharmacol 71 1129 PMID: 17227955


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Literature in this Area

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