S-Isopropylisothiourea hydrobromide

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Cat.No. 0897 - S-Isopropylisothiourea hydrobromide | C4H10N2S.HBr | CAS No. 4269-97-0
Description: iNOS inhibitor, acts at arginine binding site
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent inhibitor of NO synthase, with selectivity for the inducible form.

Technical Data

M. Wt 199.11
Formula C4H10N2S.HBr
Storage Store at RT
CAS Number 4269-97-0
PubChem ID 9813062
InChI Key SLGVZEOMLCTKRK-UHFFFAOYSA-N
Smiles Br.CC(C)SC(=N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 199.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.02 mL 25.11 mL 50.22 mL
5 mM 1 mL 5.02 mL 10.04 mL
10 mM 0.5 mL 2.51 mL 5.02 mL
50 mM 0.1 mL 0.5 mL 1 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Garvey et al (1994) Potent and selective inhibition of human nitric oxide synthases. J.Biol.Chem. 269 26669 PMID: 7523409

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999

Handy et al (1995) Effect of S-methylisothiourea on neuronal nitric oxide synthase, nociception and blood pressure in the mouse. Br.J.Pharmacol. 115 68P


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Keywords: S-Isopropylisothiourea hydrobromide, S-Isopropylisothiourea hydrobromide supplier, iNOS, inhibitors, inhibits, arginine, binding, site, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 0897, Tocris Bioscience

Citations for S-Isopropylisothiourea hydrobromide

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